Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes : A 5-year observational study

• 資料種別: 博士論文
• ISSN: 1932-6203
• タイトル: Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes : A 5-year observational study
• 巻次・部編番号: 13 4
• 著者・編者: Kishi, Fumi; Nagai, Kojiro; Takamatsu, Norimichi; Tominaga, Tatsuya; Tamaki, Masanori; Shibata, Eriko; Murakami, Taichi; Kishi, Seiji; Abe, Hideharu; Koezuka, Yasuhiko; Minagawa, Naoto; Ichien, Go; Doi, Toshio
• 著者標目: Kishi, Fumi; Nagai, Kojiro; Takamatsu, Norimichi; Tominaga, Tatsuya; Tamaki, Masanori; Shibata, Eriko; Murakami, Taichi; Kishi, Seiji; Abe, Hideharu; Koezuka, Yasuhiko; Minagawa, Naoto; Ichien, Go; Doi, Toshio
• 出版事項: PLOS
• 出版年月日等: 2018-04-06
• 出版年（W3CDTF）: 2018-04-06
• 並列タイトル等: 尿中IV型コラーゲン排泄は非糖尿病日本人一般住民の推定糸球体濾過量の低下に関与する : 5年間の観察研究; Urinary type IV collagen excretion in the Japanese general population without diabetes
• タイトル（掲載誌）: PLOS ONE
• 授与機関名: 徳島大学
• 授与年月日: 2018-05-24
• 授与年月日（W3CDTF）: 2018-05-24
• 報告番号: 甲第3197号
• 学位: 博士（医学）
• 博論授与番号: 甲第3197号
• 本文の言語コード: eng
• 件名標目: Urinary type IV collagen; eGFR; without diabetes; Japanese general population; Chronic Kidney Desease
• 対象利用者: 一般
• 一般注記: Urinary type IV collagen (U-Col4) and albumin excretion is evaluated to monitor the development of diabetic kidney disease. However, U-Col4 excretion in the general population without diabetes has not yet been fully elucidated. In this study, 1067 participants without diabetes and with urinary albumin-creatinine ratio <300 mg/gCr (normo- or microalbuminuria) who underwent an annual health examination in 2004 were enrolled and observed for 5 years. They were divided according to the amount of U-Col4 or urinary albumin excreted. The decline in estimated glomerular filtration rate (eGFR) was calculated. In participants with eGFR ≥80 mL/min, abnormal U-Col4 excretion was indicated as a significant independent risk factor for 10% eGFR change per year, which is one of the prognostic factors for the development of end-stage kidney disease. Moreover, in contrast to urinary albumin excretion, U-Col4 excretion was not related to age or kidney function, suggesting that some individuals with abnormal U-Col4 excretion can have an independent hidden risk for the development of kidney dysfunction. In conclusion, it is important to measure U-Col4 excretion in the general population without diabetes to determine changes in renal features in every individual and help detect future complications such as diabetic kidney disease. If U-Col4 excretion is abnormal, kidney manifestation should be carefully followed up, even if the kidney function and urinalysis findings are normal.
• DOI: info:doi/10.1371/journal.pone.0195523; https://doi.org/info:doi/10.1371/journal.pone.0195523
• 国立国会図書館永続的識別子: info:ndljp/pid/11116841; https://dl.ndl.go.jp/pid/11116841
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2018-07-03T21:49:10+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/112361
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp