APOB codon 4311 polymorphism is associated with hepatitis C virus infection through altered lipid metabolism

• 資料種別: 博士論文
• ISSN: 1471-230X
• タイトル: APOB codon 4311 polymorphism is associated with hepatitis C virus infection through altered lipid metabolism
• 巻次・部編番号: 18
• 著者・編者: Harada, Rie; Kimura, Masako; Sato, Yasushi; Taniguchi, Tatsuya; Tomonari, Tetsu; Tanaka, Takahiro; Tanaka, Hironori; Muguruma, Naoki; Shinomiya, Hirohiko; Honda, Hirohito; Imoto, Issei; Sogabe, Masahiro; Okahisa, Toshiya; Takayama, Tetsuji
• 著者標目: Harada, Rie; Kimura, Masako; Sato, Yasushi; Taniguchi, Tatsuya; Tomonari, Tetsu; Tanaka, Takahiro; Tanaka, Hironori; Muguruma, Naoki; Shinomiya, Hirohiko; Honda, Hirohito; Imoto, Issei; Sogabe, Masahiro; Okahisa, Toshiya; Takayama, Tetsuji
• 出版事項: Springer Nature|BioMed Central
• 出版年月日等: 2018-01-30
• 出版年（W3CDTF）: 2018-01-30
• 並列タイトル等: APOBコドン4311遺伝子多型は脂質代謝を変化させることによりC型肝炎ウイルスの感染性に関与する
• タイトル（掲載誌）: BMC Gastroenterology
• 授与機関名: 徳島大学
• 授与年月日: 2018-05-24
• 授与年月日（W3CDTF）: 2018-05-24
• 報告番号: 甲第3198号
• 学位: 博士（医学）
• 博論授与番号: 甲第3198号
• 本文の言語コード: eng
• 件名標目: Hepatitis C virus; Lipid metabolism; SNPs; ApoB
• 対象利用者: 一般
• 一般注記: Background: It has been reported that some single-nucleotide polymorphisms (SNPs) in lipid regulators such as apolipoproteins and cell surface molecules for hepatitis C virus (HCV) entry into hepatocytes are associated with HCV infection. However, it is unknown how HCV infection is affected by altered lipid metabolism resulting from the SNPs. We investigated the relationship between these SNPs and HCV infection status, and also analyzed the mechanism by which these SNPs mediate HCV infection via lipid metabolism alterations.Methods: Serum lipid and apolipoprotein profiles were tested in 158 HCV-positive and 220 HCV-negative subjects. We selected 22 SNPs in five lipid regulator genes which were related to HCV entry into hepatocytes and to lipid metabolism (APOA1, APOB, SR-B1, LDLR, and APOE), and their polymorphisms were analyzed using the PCR-sequencespecific oligonucleotide probe-Luminex method.Results: An APOB N4311S (g.41553a > g) SNP, rs1042034, was significantly associated with HCV positivity; the HCV positivity rate for the minor allele AA genotype was significantly higher than for genotype AG + GG (P = 0.016). Other SNPs except for APOB P2712L SNP rs676210, which is in linkage disequilibrium with rs1042034, showed no significant difference in genotype distribution. The serum level of low density lipoprotein-cholesterol (LDL-C) in the genotype AA group was significantly lower than in the genotype non-AA group (P = 0.032), whereas the triglyceride (TG) level was significantly higher (P = 0.007).Conclusion: An APOB SNP, rs1042034, is closely associated with HCV infection through lipid metabolism alteration. The minor allele AA genotype might contribute to facilitating serum LDL uptake into hepatocytes via LDLR by modifying their affinity and interaction and may have an influence on HCV infection by their entry to the liver through the LDLR.
• DOI: info:doi/10.1186/s12876-018-0747-5; https://doi.org/info:doi/10.1186/s12876-018-0747-5
• 国立国会図書館永続的識別子: info:ndljp/pid/11116842; https://dl.ndl.go.jp/pid/11116842
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2018-07-03T21:49:10+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/111808
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp