Preliminary evidence that rivastigmine-induced inhibition of serum butyrylcholinesterase activity improves behavioral symptoms in Japanese patients with Alzheimer's disease

• 資料種別: 博士論文
• タイトル: Preliminary evidence that rivastigmine-induced inhibition of serum butyrylcholinesterase activity improves behavioral symptoms in Japanese patients with Alzheimer's disease
• 著者・編者: 坂東, 伸泰
• 著者標目: 坂東, 伸泰
• 出版年月日等: 2017-03-03
• 出版年（W3CDTF）: 2017-03-03
• 授与機関名: 香川大学
• 授与年月日: 2017-03-03
• 授与年月日（W3CDTF）: 2017-03-03
• 報告番号: 乙第279号
• 学位: 博士（医学）
• 博論授与番号: 乙第279号
• 本文の言語コード: eng
• 著者別名: Bando, Nobuyasu
• 件名標目: Alzheimer's disease; behavioral symptom; butyrylcholinesterase; cholinesterase inhibitor; rivastigmine
• 対象利用者: 一般
• 一般注記: AimTo investigate whether the inhibitory rate of serum butyrylcholinesterase (BuChE) activity in Japanese patients with Alzheimer's disease is correlated with cognitive function, behavioral symptoms and caregiver burden.; MethodsA total of 61 patients with mild to moderately severe Alzheimer's disease who were not undergoing cholinesterase enzyme inhibitor/memantine combinatorial treatment received a rivastigmine (18 mg) patch for 24 weeks. The rate of inhibition of BuChE was correlated with scores obtained on cognitive (Mini-Mental State Examination), behavioral (the Japanese version of the modified Crichton Geriatric Behavioral Rating Scale [CGBRS] and Vitality Index [VI]) and burden (the Japanese version of Zarit Burden Inventory [ZBI]) scales; and the Clinical Global Impression of Change scale.; ResultsThe serum BuChE activity showed a significant decrease after 24 weeks compared with baseline (P < 0.001). Overall, significant effects were found in the Mini-Mental State Examination score, VI score and modified CGBRS score. We then divided patient groups into a high inhibitory rate (≥40%) group and a low inhibitory rate (<40%) group; there were significant improvements in the Mini-Mental State Examination score, VI score and modified CGBRS score in both groups. However, favorable results were seen in cooperation, restlessness and leisure on modified CGBRS subscales in the high inhibitory rate group (P < 0.001, P = 0.007, P < 0.001, respectively), and rehabilitation and other activities on VI subscales in the high inhibitory rate group (P = 0.005) compared with those in the low inhibitory rate group.; ConclusionsDemonstrable significant improvements in behavioral symptoms, such as low cooperation, restlessness or low activities in patients with Alzheimer's disease, were achieved on inhibition of BuChE at a rate of 40% or more. Geriatr Gerontol Int 2017; 17: 1306-1312.
• DOI: info:doi/10.1111/ggi.12865; https://doi.org/info:doi/10.1111/ggi.12865
• 国立国会図書館永続的識別子: info:ndljp/pid/11151097; https://dl.ndl.go.jp/pid/11151097
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2018-09-03T21:27:21+09:00
• 作成日（W3CDTF）: 2020-10-27
• 記録形式（IMT）: PDF; application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://kagawa-u.repo.nii.ac.jp/records/327
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-08-05 再収集