Elevated Preoperative Serum CEA Levels Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma Through the Epithelial-Mesenchymal Transition 3

• 資料種別: 博士論文
• ISSN: 0250-7005
• タイトル: Elevated Preoperative Serum CEA Levels Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma Through the Epithelial-Mesenchymal Transition
• 巻次・部編番号: 37 3
• 著者・編者: Yoshikawa, Masato; Morine, Yuji; Ikemoto, Tetsuya; Imura, Satoru; Higashijima, Jun; Iwahashi, Shuichi; Saito, Yu; Takasu, Chie; Yamada, Shinichiro; Ishikawa, Daichi; Teraoku, Hiroki; Takata, Atsushi; Yoshimoto, Toshiaki; Shimada, Mitsuo
• 著者標目: Yoshikawa, Masato; Morine, Yuji; Ikemoto, Tetsuya; Imura, Satoru; Higashijima, Jun; Iwahashi, Shuichi; Saito, Yu; Takasu, Chie; Yamada, Shinichiro; Ishikawa, Daichi; Teraoku, Hiroki; Takata, Atsushi; Yoshimoto, Toshiaki; Shimada, Mitsuo
• 出版事項: International Institute of Anticancer Research
• 出版年月日等: 2017-03-01
• 出版年（W3CDTF）: 2017-03-01
• 並列タイトル等: 肝細胞癌患者における術前血清CEA値上昇は上皮間葉転換を介して予後不良と関連する; Elevated Preoperative Serum CEA Level Is with Hepatocellular Carcinoma with Poor Prognosis Through the Epithelial-Mesenchymal Transition
• タイトル（掲載誌）: Anticancer Research
• 授与機関名: 徳島大学
• 授与年月日: 2018-07-26
• 授与年月日（W3CDTF）: 2018-07-26
• 報告番号: 甲第3204号
• 学位: 博士（医学）
• 博論授与番号: 甲第3204号
• 本文の言語コード: eng
• 件名標目: CEA; CEACAM; epithelial mesenchymal transition; hepatocellular carcinoma
• 対象利用者: 一般
• 一般注記: Background: Serum carcinoembryonic antigen (CEA) is used as an indicator of tumor progression in a variety of carcinomas. A subset of patients with hepatocellular carcinoma (HCC) exhibit increased serum CEA level, but the significance of this is unclear. In this study, we investigated the prognosis of patients with HCC with increased serum CEA, and explored the correlations with expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and epithelial–mesenchymal transition (EMT) and tumor angiogenesis. Materials and Methods: One hundred and twenty-three patients with HCC who underwent radical resection were divided into two groups according to a cut-off value of 5.0 ng/ml for serum CEA: high (n=24) and normal (n=99) groups. We compared the clinicopathological factors with serum CEA levels and its correlations with CEACAM1 expression, EMT-related factors and microvessel density (MVD) of tumor tissues by immunohistochemistry. Results: In the high CEA group, the disease-free survival (DFS) rate was significantly worse than in the normal CEA group. Multivariate analysis revealed that a high CEA level was an independent factor predictive of recurrence. Furthermore, increased serum CEA levels were positively correlated with CEACAM1 expression. Moreover, CEACAM1 expression was positively correlated with expression of EMT-related factors and MVD of tumor tissues. Conclusion: Increased serum CEA level reflected CEACAM1 expression and was an independent factor predictive of recurrence in HCC through EMT and tumor angiogenesis.
• DOI: info:doi/10.21873/anticanres.11430; https://doi.org/info:doi/10.21873/anticanres.11430
• 国立国会図書館永続的識別子: info:ndljp/pid/11151116; https://dl.ndl.go.jp/pid/11151116
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2018-09-03T21:27:21+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://repo.lib.tokushima-u.ac.jp/112034
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp