並列タイトル等牛肺感染症を引き起こしたマイコバクテリウム・アビウム・ホミニシウスMycobacterium avium subspecies hominissuisの遺伝系統
タイトル（掲載誌）Infection, Genetics and Evolution
授与機関名Nagasaki University (長崎大学)
一般注記Mycobacterium avium subspecies hominissuis (MAH) is an important cause of infection in human pulmonary and swine intestinal cases. Although MAH is isolated from environmental sources frequently, infections of other animals have rarely been analysed. Recently, we detected granulomatous inflammation in bovine lung as an abnormal postmortem inspection case. To ascertain its genetic profile, we conducted a variable numbers of tandem repeats (VNTR) analysis and genomic characterization using deep sequencing. The VNTR type was a unique profile that differed from reported genotypes, but it was assigned within a broad genotypic complex of isolates from human patients and bathrooms. Genomic comparison with 116 registered genome sequences of the subspecies revealed that the strain was separate from five major genetic population groups proposed previously. Although the infection source remains unclear, its isolation from various resources such as animal infection cases should be elucidated more extensively to reveal its genetic diversity and ecological context.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1095号 学位授与年月日:平成30年9月5日
Author: Shiomi Yoshida, Tsubasa Araki, Tomohito Asai, Kazunari Tsuyuguchi, Kentaro Arikawa, Tomotada Iwamoto, Chie Nakajima, Yasuhiko Suzuki, Kenji Ohya, Tokuma Yanai, Takayuki Wada, Taro Yamamoto
Citation: Infection, Genetics and Evolution, 62, pp.122-129; 2018
Nagasaki University (長崎大学), 博士(医学) (2018-09-05)
DOIinfo:doi/10.1016/j.meegid.2018.04.013
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