Insulin-like growth factor Ⅱmessenger RNA-binding protein-3 is an indicator of malignant phyllodes tumor of the breast

• 資料種別: 博士論文
• タイトル: Insulin-like growth factor Ⅱmessenger RNA-binding protein-3 is an indicator of malignant phyllodes tumor of the breast
• 著者・編者: 瀧澤, 克実
• 著者標目: 瀧澤, 克実
• 出版年月日等: 2017-12-31
• 出版年（W3CDTF）: 2017-12-31
• 並列タイトル等: Insulin-like growth factor Ⅱmessenger RNA-binding protein-3は乳腺悪性葉状腫瘍の指標になる
• 寄与者: 橋爪, 誠; 中島, 康晴; 前原, 喜彦
• 授与機関名: 九州大学
• 授与年月日: 2017-12-31
• 授与年月日（W3CDTF）: 2017-12-31
• 報告番号: 乙第08699号
• 学位: 博士（医学）
• 博論授与番号: 乙第08699号
• 本文の言語コード: jpn
• 対象利用者: 一般
• 一般注記: The aim of this study was to elucidate the clinicopathological and prognostic significance of the expressions of insulin-like growth factor II mRNA-binding protein-3 (IMP3) and epidermal growth factor receptor (EGFR) in phyllodes tumors (PTs). Immunohistochemical staining for IMP3 and EGFR was performed in 130 cases of primary PTs (83 benign, 28 borderline, 19 malignant), 34 recurrent/metastatic PTs, and 26 fibroadenomas (FAs). Among the primary tumors, a high expression of IMP3 was significantly more frequently present in malignant PTs (17/19, 89%) than in the FAs (0/26, 0%), benign PTs (0/83, 0%) and borderline PTs (3/28, 11%). The recurrent and metastatic lesions of malignant PTs also showed high IMP3 expression (3/5 [60%] and 6/6 [100%], respectively). Most malignant PTs showed strong IMP3 expression at the interductal area or more diffusely, whereas weak and focal (low) expression of IMP3 was limited to the periductal area in FAs and benign PTs. EGFR overexpression was significantly correlated with tumor grade and high IMP3 expression. Overexpressions of IMP3 and EGFR were significantly associated with shorter periods of metastasis-free and disease-free survival. The results suggest that high expressions of IMP3 and EGFR with a characteristic staining pattern may be helpful for both identifying malignant PT and predicting the prognosis of these tumors.; PubMed番号 : 27137988
• DOI: 10.15017/1928638; https://doi.org/10.15017/1928638
• 国立国会図書館永続的識別子: info:ndljp/pid/11178414; https://dl.ndl.go.jp/pid/11178414
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2018-11-05T10:48:21+09:00
• 作成日（W3CDTF）: 2018-05-09
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://dx.doi.org/10.15017/1928638; http://hdl.handle.net/2324/1928638
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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