1H-Magnetic Resonance Spectroscopy Study of Glutamate-related Abnormality in Bipolar Disorder

• 資料種別: 博士論文
• ISSN: 0165-0327
• タイトル: 1H-Magnetic Resonance Spectroscopy Study of Glutamate-related Abnormality in Bipolar Disorder
• 巻次・部編番号: 208
• 著者・編者: Kubo, Hiroko; Nakataki, Masahito; Sumitani, Satsuki; Iga, Jun-ichi; Numata, Shusuke; Kameoka, Naomi; Watanabe, Shin-ya; Umehara, Hidehiro; Kinoshita, Makoto; Inoshita, Masatoshi; Tamaru, Mai; Ohta, Masashi; Nakayama-Yamauchi, Chiaki; Funakoshi, Yasuhiro; Harada, Masafumi; Ohmori, Tetsuro
• 著者標目: Kubo, Hiroko; Nakataki, Masahito; Sumitani, Satsuki; Iga, Jun-ichi; Numata, Shusuke; Kameoka, Naomi; Watanabe, Shin-ya; Umehara, Hidehiro; Kinoshita, Makoto; Inoshita, Masatoshi; Tamaru, Mai; Ohta, Masashi; Nakayama-Yamauchi, Chiaki; Funakoshi, Yasuhiro; Harada, Masafumi; Ohmori, Tetsuro
• 出版事項: Elsevier
• 出版年月日等: 2016-10-08
• 出版年（W3CDTF）: 2016-10-08
• 並列タイトル等: 双極性障害におけるグルタミン酸神経伝達異常に関するMRS研究
• タイトル（掲載誌）: Journal of Affective Disorders
• 授与機関名: 徳島大学
• 授与年月日: 2016-11-24
• 授与年月日（W3CDTF）: 2016-11-24
• 報告番号: 甲第3000号
• 学位: 博士（医学）
• 博論授与番号: 甲第3000号
• 本文の言語コード: eng
• 件名標目: Bipolar disorder; glutamate; lithium; sodium valproate; magnetic resonance spectroscopy; Glutamine
• 対象利用者: 一般
• 一般注記: Background: Previous studies of patients with bipolar disorder (BD) using magnetic resonance spectroscopy (MRS) have shown neurophysiological abnormalities related to the glutamate (Glu)-glutamine (Gln) cycle, membrane turnover, and neuronal integrity, although the results were neither consistent nor conclusive. Recently it has been reported the Gln/Glu ratio is the most useful index, quantifying neuronal-glial interactions and the balance of glutamatergic metabolites In this MRS study, we elucidated the abnormalities of metabolites in a larger sample of patients with BD with a high-field MRI system.Methods: Sixty-two subjects (31 patients with BD and 31 healthy controls [HC]) underwent 3T proton MRS (1H-MRS) of the anterior cingulate cortex (ACC) and left basal ganglia (ltBG) using a stimulated echo acquisition mode (STEAM) sequence.Results: After verifying the data quality, 20 patients with BD and 23 age- and gender-matched HCs were compared using repeated-measures analysis of covariance (ANCOVA). Compared to the HC group, the BD group showed increased levels of Gln, creatine (Cr), N-acetyl aspartate (NAA), choline (Cho), and an increased ratio of Gln to Glu in the ACC, and increased Gln and Cho in the ltBG. These findings remained after the participants with BD were limited to only euthymic patients. After removing the influence of lithium (Li) and sodium valproate (VPA), we observed activated glutamatergic neurotransmission in the ACC but not in the ltBG. Limitations: The present findings are cross-sectional and metabolites were measured in only two regions.Conclusions: Our results support a wide range of metabolite changes in patients with BD involved in glutamatergic neurotransmission, membrane turnover, and neuronal integrity. Moreover, the elevation of Gln/Glu ratio suggested that hyperactivity of glutamatergic neurotransmission in the ACC is a disease marker for BD.
• DOI: info:doi/10.1016/j.jad.2016.08.046; https://doi.org/info:doi/10.1016/j.jad.2016.08.046
• 国立国会図書館永続的識別子: info:ndljp/pid/11194401; https://dl.ndl.go.jp/pid/11194401
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2018-12-03T16:15:19+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/109987
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp