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博士論文
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病態生理学に基づいた下痢症子牛の栄養輸液療法に関する研究
- 国立国会図書館永続的識別子
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- The aim of present study was to identify what kind of formulation is appropriate for oral and intravenous nutritional infusion therapy in calves with ...
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デジタル
- 資料種別
- 博士論文
- 著者・編者
- 塚野, 健志
- 出版年月日等
- 2018-09-30
- 出版年(W3CDTF)
- 2018-09-30
- 並列タイトル等
- Study on nutritional infusion therapy in calves with diarrhea based on pathophysiology
- 授与機関名
- 酪農学園大学
- 授与年月日
- 2018-09-30
- 授与年月日(W3CDTF)
- 2018-09-30
- 報告番号
- 甲第179号
- 学位
- 獣医学
- 博論授与番号
- 甲第179号
- 本文の言語コード
- jpn
- 一般注記
- The aim of present study was to identify what kind of formulation is appropriate for oral and intravenous nutritional infusion therapy in calves with diarrhea. In chapter 1 discussed the state of fluid therapy for calves with diarrhea in Japan, and noted the necessity of nutrient infusion. In chapter 2, the aim of present survey was to identify risk factors of laboratory findings for mortality in calves with diarrhea. A retrospective analysis was conducted utilizing medical records of 221 diarrheic calves. As a result, hypoglycemia (OR 3.09; 95% CI 1.22-7.87; p=0.02) and failure of respiratory compensation (OR 2.63; 95% CI 1.05-6.62; p=0.04) were the major risk factors associated with a negative outcome in diarrheic calves. Indeed, the addition of glucose to IV fluid solutions is widely used to provide energy, but malnutrition is serious problem in diarrheic calves with hypoglycemia. These results suggest that to consider the next step for nutritional management in diarrheic calves is important. In chapter 3 aimed to confirm necessity of amino acid supply in calves with diarrhea and respiratory diseases. As a result, the blood pH and plasma concentrations of total amino acids (TAA) and branched chain amino acids (BCAA) were significantly and negatively correlated in calves with diarrhea. In other words, acidemia activated the catabolism of protein. Similarly, the calves with Mycoplasma bronchopneumonia, a respiratory disease, were characterized by significantly lower in serum TAA and BCAA. These results indicated that supplying amino acids to diarrheic calves with acidemia and respiratory diseases with hyper inflammation state was important. In chapter 4, oral or intravenous nutrient infusions for diarrheic calves with different pathophysiology features were examined. In section 1, four different compositions of oral electrolyte solutions (OES) were prepared to test how differences in the composition of OES affect dehydration and prevent catabolism. Results of present study demonstrated that OES with high sodium (Na) concentration (100.1 mM) and the ratio of glucose (Glu) and glycine (Gly) to Na was 0.6 : 0.6 : 1.0 has effect of increasing the blood volume. On the other hand, OES with high Glu concentration (116.8 mM) and the ratio of Glu to Gly was 1.0 : 1.0 has catabolism prevention effect. This suggests that it is necessary to use these OES properly. The OES with high Na concentration should be used in the early stages of diarrhea for calves with dehydration and metabolic acidosis, but not in the later stages of exhaustion. The OES with high Glu concentration may beneficial for wasting diarrheic calves with dehydration. In section 2 evaluated the effects of solutions with or without dextrose intravenously administered to diarrheic calves, with beta-hydroxybutyrate (BHBA) concentrations as an index. As a result, the addition of dextrose to intravenous fluid solutions did not affect the correcting dehydration. In addition, catabolism prevention was observed only intravenous infusion of solution with dextrose. These results suggest that a solution with dextrose could be beneficial for wasting diarrheic calves. In section 3 assessed the advantages of dextrose and amino acid mixture solution as parenteral nutrition (PN) therapy for calves with Cryptosporidium parvum (C. parvum) diarrhea. Sixteen diarrheic calves were randomly assigned to receive PN (PPN group, n=8) or only dextrose solution (Dex group, n=8). Plasma diamine oxidase (DAO) activity in the PPN group at the end of infusion (118.3 ± 42.3 IU/mL) was significantly increased compared with that before fluid infusion (81.5 ± 25.8 IU/mL), but there were no significant differences in the Dex group. Increased plasma DAO activity indicated repair of the damaged intestine, as a result, the treatment period for the PPN group was significantly shorter than that for the Dex group. Our results suggested that not only dextrose but dextrose and amino acid mixture solution as PN therapy was recommended in calves with C. parvum diarrhea.The PN therapy has been widely used for humans, but it is not yet standard in large animal medical treatment. The present study demonstrated that the PN therapy could be beneficial for clinical use in calves with diarrhea based on scientific basis. The PN therapy in this study was economical and executable in clinical site. Future studies to examine the prescription of PN infusion solution with an amino acid ratio, lipid, vitamin and trace elements suitable for calf diarrhea are needed.開始ページ : 1終了ページ : 93
- 国立国会図書館永続的識別子
- info:ndljp/pid/11217230
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- コレクション(障害者向け資料:レベル1)
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- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- 収集根拠
- 博士論文(自動収集)
- 受理日(W3CDTF)
- 2019-01-04T08:16:43+09:00
- 作成日(W3CDTF)
- 2018-12-11
- 記録形式(IMT)
- application/pdf
- オンライン閲覧公開範囲
- 国立国会図書館内限定公開
- デジタル化資料送信
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- 可
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館デジタルコレクション