Intra-follicular kisspeptin levels are related to oocyte maturation and gonadal hormones in patients who are undergoing assisted reproductive technology 4

• 資料種別: 博士論文
• ISSN: 1447-0578
• タイトル: Intra-follicular kisspeptin levels are related to oocyte maturation and gonadal hormones in patients who are undergoing assisted reproductive technology
• 巻次・部編番号: 16 4
• 著者・編者: Taniguchi, Yuka; Kuwahara, Akira; Tachibana, Ayaka; Yano, Yuya; Yano, Kiyohito; Yamamoto, Yuri; Yamasaki, Mikio; Iwasa, Takeshi; Hinokio, Kenji; Matsuzaki, Toshiya; Irahara, Minoru
• 著者標目: Taniguchi, Yuka; Kuwahara, Akira; Tachibana, Ayaka; Yano, Yuya; Yano, Kiyohito; Yamamoto, Yuri; Yamasaki, Mikio; Iwasa, Takeshi; Hinokio, Kenji; Matsuzaki, Toshiya; Irahara, Minoru
• 出版事項: Wiley|Japan Society for Reproductive Medicine
• 出版年月日等: 2018-09-16
• 出版年（W3CDTF）: 2018-09-16
• 並列タイトル等: 生殖補助医療を行っている患者において卵胞液中のキスペプチン濃度は卵成熟および性腺ホルモン値と関連している
• タイトル（掲載誌）: Reproductive Medicine and Biology
• 授与機関名: 徳島大学
• 授与年月日: 2018-09-27
• 授与年月日（W3CDTF）: 2018-09-27
• 報告番号: 甲第3219号
• 学位: 博士（医学）
• 博論授与番号: 甲第3219号
• 本文の言語コード: eng
• 件名標目: Assisted reproductive technology; estradiol; follicular fluid; kisspeptin; mature oocyte
• 対象利用者: 一般
• 一般注記: Purpose: To assess the kisspeptin concentrations in follicular fluid and their relationship with clinical outcomes during assisted reproductive technology.Methods: Thirty-nine patients who were aged 24-40 years and underwent oocyte retrieval for in vitro fertilization/intracytoplasmic sperm injection participated in this study. In 65 follicular fluid samples that had been obtained from 30 patients and their blood samples, the kisspeptin levels were measured in order to investigate the correlations with their gonadal hormone levels. Venous blood samples were collected from 14 patients to investigate their plasma kisspeptin levels across different phases of assisted reproductive technology.Results: The follicular fluid kisspeptin level was significantly higher than that of the plasma level and was positively associated with the follicular fluid estradiol concentration and with the serum estradiol and number of mature oocytes. In the plasma, the maximum concentration of kisspeptin was observed on the day of ovum pick-up and on the day of embryo transfer during ovarian stimulation for assisted reproductive technology.Conclusion: Kisspeptin was present in the follicular fluid and the plasma kisspeptin concentration was affected by ovarian stimulation. Kisspeptin appears to affect oocyte maturation and ovulation.
• DOI: info:doi/10.1002/rmb2.12056; https://doi.org/info:doi/10.1002/rmb2.12056
• 国立国会図書館永続的識別子: info:ndljp/pid/11217340; https://dl.ndl.go.jp/pid/11217340
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2019-01-04T08:16:43+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/112881
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp