Effect of Npt2b deletion on intestinal and renal inorganic phosphate (Pi) handling 3

• 資料種別: 博士論文
• ISSN: 1342-1751
• タイトル: Effect of Npt2b deletion on intestinal and renal inorganic phosphate (Pi) handling
• 巻次・部編番号: 22 3
• 著者・編者: Ikuta, Kayo; Segawa, Hiroko; Sasaki, Shohei; Hanazaki, Ai; Fujii, Toru; Kushi, Aoi; Kawabata, Yuka; Kirino, Ruri; Sasaki, Sumire; Noguchi, Miwa; Kaneko, Ichiro; Tatsumi, Sawako; Ueda, Otoya; Wada, Naoko A.; Tateishi, Hiromi; Kakefuda, Mami; Kawase, Yosuke; Ohtomo, Shuichi; Ichida, Yasuhiro; Maeda, Akira; Jishage, Kou-ichi; Horiba, Naoshi; Miyamoto, Ken-ichi
• 著者標目: Ikuta, Kayo; Segawa, Hiroko; Sasaki, Shohei; Hanazaki, Ai; Fujii, Toru; Kushi, Aoi; Kawabata, Yuka; Kirino, Ruri; Sasaki, Sumire; Noguchi, Miwa; Kaneko, Ichiro; Tatsumi, Sawako; Ueda, Otoya; Wada, Naoko A.; Tateishi, Hiromi; Kakefuda, Mami; Kawase, Yosuke; Ohtomo, Shuichi; Ichida, Yasuhiro; Maeda, Akira; Jishage, Kou-ichi; Horiba, Naoshi; Miyamoto, Ken-ichi
• 出版事項: Japanese Society of Nephrology|Springer
• 出版年月日等: 2017-11-11; 22 3
• 出版年（W3CDTF）: 2017-11-11
• 並列タイトル等: 腸管および腎臓でのリン代謝におけるNpt2b欠損の影響; Conditional deletion of Npt2b in phosphate transport
• タイトル（掲載誌）: Clinical and Experimental Nephrology
• 授与機関名: 徳島大学
• 授与年月日: 2018-03-23
• 授与年月日（W3CDTF）: 2018-03-23
• 報告番号: 甲第3139号
• 学位: 博士（栄養学）
• 博論授与番号: 甲第3139号
• 本文の言語コード: eng
• 件名標目: Intestine; Transcellular transport-paracellular transport
• 対象利用者: 一般
• 一般注記: BackgroundHyperphosphatemia is common in chronic kidney disease and is associated with morbidity and mortality. The intestinal Na+-dependent phosphate transporter Npt2b is thought to be an important molecular target for the prevention of hyperphosphatemia. The role of Npt2b in the net absorption of inorganic phosphate (Pi), however, is controversial.MethodsIn the present study, we made tamoxifen-inducible Npt2b conditional knockout (CKO) mice to analyze systemic Pi metabolism, including intestinal Pi absorption.ResultsAlthough the Na+-dependent Pi transport in brush-border membrane vesicle uptake levels were significantly decreased in the distal intestine of Npt2b CKO mice compared with control mice, plasma Pi and fecal Pi excretion levels were not significantly different. Data obtained using the intestinal loop technique showed that Pi uptake in Npt2b CKO mice was not affected at a Pi concentration of 4 mM, which is considered the typical luminal Pi concentration after meals in mice. Claudin, which may be involved in paracellular pathways, as well as claudin-2, 12, and 15 protein levels were significantly decreased in the Npt2b CKO mice. Thus, Npt2b deficiency did not affect Pi absorption within the range of Pi concentrations that normally occurs after meals.ConclusionThese findings indicate that abnormal Pi metabolism may also be involved in tight junction molecules such as Cldns that are affected by Npt2b deficiency.
• DOI: info:doi/10.1007/s10157-017-1497-3; https://doi.org/info:doi/10.1007/s10157-017-1497-3
• 国立国会図書館永続的識別子: info:ndljp/pid/11287722; https://dl.ndl.go.jp/pid/11287722
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2019-06-03T12:31:31+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/111601
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp