並列タイトル等Indirect regulation of PCSK9 gene in inflammatory response by Porphyromonas gingivalis infection
Porphyromonas gingivalis感染時炎症応答におけるPCSK9遺伝子発現の制御機構
一般注記Pro-protein convertase subtilisin/kexin type 9 (PCSK9), a secreted serine protease, regulates serum low-density lipoprotein (LDL) cholesterol levels by targeting the degradation of LDL receptor (LDLR) in the liver. Although previous reports describe elevated levels of PCSK9 in patients with periodontitis, the mechanisms that trigger this increase in serum PCSK9 levels and induce the related inflammatory response remain unclear. In an unc93b1-deficient mouse of Porphyromonas gingivalis infection, nucleic acid antigen recognition via Tolllike receptors was found to promote PCSK9 production, suggesting an indirect role for tumor necrosis factor-α as an inducer of PCSK9 in contrast to that reported in previous studies. Furthermore, PCSK9 production was independent of the TIR domain-containing adapter-inducing interferon-β-dependent signaling pathway. These results indicate that changes in LDLR expression precede an increase in the serum PCSK9 level in the context of an infectious disease such as periodontitis.
学位の種類: 博士（歯学）. 報告番号: 甲第4575号. 学位記番号: 新大院博（歯）甲第424号. 学位授与年月日: 平成31年3月25日
Heliyon. 2019, 5(2), e01210
新大院博（歯）甲第424号
元資料の権利情報 : 【○!C】 2018 The Authors. Published by Elsevier Ltd.
開始ページ : 1
終了ページ : 14
DOIinfo:doi/10.1016/j.heliyon.2018.e01111
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