ホスホリルコリン経鼻投与によるアレルギー性鼻炎発症の抑制

• 資料種別: 博士論文
• タイトル: ホスホリルコリン経鼻投与によるアレルギー性鼻炎発症の抑制
• 巻次・部編番号: 128 7
• 著者・編者: 宮下, 圭一
• 著者標目: 宮下, 圭一
• 出版事項: John Wiley & Sons, Inc.
• 出版年月日等: 2018; 128 7
• 出版年（W3CDTF）: 2018
• 並列タイトル等: Intranasal Immunization with Phosphorylcholine Suppresses Allergic Rhinitis in Mice
• タイトル（掲載誌）: The Laryngoscope
• 授与機関名: 鹿児島大学
• 授与年月日: 2019-01-20
• 授与年月日（W3CDTF）: 2019-01-20
• 報告番号: 乙総論第33号
• 学位: 博士(医学); Doctor of Philosophy in Medical Science
• 博論授与番号: 乙総論第33号
• 本文の言語コード: eng
• 件名標目: allergic rhinitis; phosphorylcholine; NALT; dendritic cells; IL-4; IL-12
• NDC: 492
• 対象利用者: 一般
• 一般注記: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Objectives/Hypothesis: Intranasal immunization with phosphorylcholine (PC) is known to reduce IgE production. However, its effects on the occurrence of allergic rhinitis (AR) are unknown.Objectives: This study was performed to evaluate the effects of PC-keyhole limpet hemocyanin (PC-KLH) and to examine the effects on the occurrence of AR in a murine model of AR.Study Design: In vivo study using an animal model.Methods: Forty-five female BALB/c mice were divided into 3 groups; those pretreated with intranasal administration of PC-keyhole limpet hemocyanin (PC-KLH) followed by intra-peritoneal sensitization and nasal challenge with ovalbumin (OVA) (Group A), those untreated with PC-KLH followed by sensitization and nasal challenge with OVA (Group B), and those untreated with PC-KLH or OVA as a control (Group C). Nasal symptoms, allergic inflammation in the nasal mucosa, OVA specific IgE production, and cytokine profile were compared among those three groups. Further, dendritic cells (DCs) were isolated from splenic cells and PC-KLH-stimulated IL-12p40 production was measured.Results: The mice pretreated with PC-KLH showed lower allergic nasal symptoms and inflammation compared to untreated mice. The levels of total IgE and OVA-specific IgE in serum, and IL-4 production by nasal and splenic CD4+ T cells were significantly reduced by PC-KLH pretreatment. Furthermore, IL-12p40 production by DCs was induced by PC-KLH in a dose-dependent manner.Conclusion: Intranasal administration of PC-KLH suppressed allergic inflammation in nasal mucosa and antigen-specific IgE production by down regulating Th2-type immune response. Intranasal immunization with PC might be useful to prevent AR and upper airway bacterial infection.
• DOI: info:doi/10.1002/lary.27030; https://doi.org/info:doi/10.1002/lary.27030
• 国立国会図書館永続的識別子: info:ndljp/pid/11377972; https://dl.ndl.go.jp/pid/11377972
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2019-11-04T14:30:53+09:00
• 作成日（W3CDTF）: 2019-01-28
• 記録形式（IMT）: PDF; application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 原資料（URI）: https://onlinelibrary.wiley.com/journal/15314995#pane-01cbe741-499a-4611-874e-1061f1f4679e01
• 掲載誌（URI）: http://hdl.handle.net/10232/00030435
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

目次

2023-08-05 再収集

2023-08-05 再収集

2023-08-05 再収集

2023-08-05 再収集

2024-01-19 再収集