並列タイトル等唾液微弱化学発光測定法を用いたストレス測定の有効性
タイトル（掲載誌）Japanese Journal of Occupational Medicine and Traumatology
一般注記doctoral
医学系研究科
The incidence of stress-induced psychiatric disorders has increased rapidly in recent years. Screening for stress markers enables early detection and treatment of conditions in which stress responses affect health. Salivary ultra-weak chemiluminescence (UCL) can detect peroxidase and thiocyanate ions, which are secreted and increased in saliva under stress. Forty-four patients with diabetes mellitus who were admitted for diabetic education because of their high prevalence of depression and 14 healthy hospital staff members were included. Level variations of stress-related substances in saliva were measured by UCL. Simultaneously, salivary levels of cortisol and chromograninA (CgA) were measured, and the short form of the Profile of Mood States questionnaire was administered. Chemiluminescence intensity correlated with increases in depression-dejection subscale scores, and had a positive and negative correlation with CgA and cortisol levels, respectively. The hospital staff and patients differed significantly in chemiluminescence intensities, cortisol levels, and depression-dejection scores. In conclusion, UCL intensity was correlated with depression scores and levels of classical stress markers, with significant differences between hospital staff and patients. UCL intensity may thus allow the measurement of increases in psychological stress. Furthermore, because saliva absorbed by filter paper can be used, samples can easily be collected and analyzed.
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