並列タイトル等Influences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese women
学位博士(医学)
Doctor of Philosophy in Medical Science
一般注記博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Aim: The purpose of the present study was to investigate the influences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese women.Materials and methods: A total of 68 Japanese women were recruited between July 2016 and May 2018 at the Department of Obstetrics and Gynecology, Kagoshima University Hospital. This study included three subjects. Subject 1: A total of 57 premenopausal women were divided into two groups: those with estrogen-dependent diseases (n=19) and estrogen-independent diseases (n=38). Subject 2: A total of 26 premenopausal women were divided into two groups: those with premature oophorectomy (n=15) and ovarian preservation (n=11) during gynecological surgery. Subject 3: A total of 11 postmenopausal women who had received oophorectomy during their cancer operations were divided into two groups: those with postoperative anti-cancer chemotherapy (n=6) and those without chemotherapy (control, n=5). Facial skin parameters including skin age, relative skin age (i.e., skin age minus chronological age) and skin health conditions were assessed using a bioelectrical impedance analysis device.Results: 1) Relative skin age was significantly younger in women with estrogen-dependent diseases than in those with estrogenindependent diseases (-1.0 ± 1.4 vs. 2.5 ± 0.6 years, respectively, p<0.01). 2) Longitudinal changes in relative skin age at 6 months postoperatively in the oophorectomy group had progressed significantly compared with the ovarian preservation group (3.5 ± 1.4 vs. - 0.2 ± 0.8 years, respectively, p<0.05). 3) Longitudinal changes in relative skin age at 12 months after chemotherapy in postmenopausal women who received 6 courses of postoperative anti-cancer chemotherapy had progressed significantly compared with control (10.5 ± 3.3 vs. -3.8 ± 3.4 years, respectively, p<0.05). The ratio of young skin conditions was also significantly decreased after chemotherapy (from 5/6 to 1/6, respectively, p<0.05).Conclusions: Women with estrogen-dependent diseases maintain a younger facial skin age than those with estrogen-independent diseases. However, skin aging is accelerated by premature oophorectomy and markedly accelerated by anti-cancer chemotherapy.LIU Shuice, ORITA Yuji, IWAMOTO Ichiro, SAKIHAMA Mika, TOGAMI Shinichi, OUCHI Tsutomu, KOBAYASHI HiroakiInfluences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese womenMedical journal of Kagoshima University 71(1-3) 23-34, (2019)
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