Trajectories of class-switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy

• 資料種別: 博士論文
• ISSN: 2050-4527
• タイトル: Trajectories of class-switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy
• 巻次・部編番号: 7 2
• 著者・編者: Irahara, Makoto; Shinahara, Wakako; Sugimoto, Mayumi; Ogawa, Yukiko; Shitsukawa, Keiji; Kubota, Kenji; Yang, Limin; Ohya, Yukihiro; Saito, Hirohisa; Kagami, Shoji; Arisawa, Kokichi; Kido, Hiroshi
• 著者標目: Irahara, Makoto; Shinahara, Wakako; Sugimoto, Mayumi; Ogawa, Yukiko; Shitsukawa, Keiji; Kubota, Kenji; Yang, Limin; Ohya, Yukihiro; Saito, Hirohisa; Kagami, Shoji; Arisawa, Kokichi; Kido, Hiroshi
• 出版事項: Wiley
• 出版年月日等: 2019-03-11
• 出版年（W3CDTF）: 2019-03-11
• 並列タイトル等: 乳児期早期における鶏卵、牛乳アレルゲン特異的免疫グロブリンのクラススイッチを伴うアイソタイプ形成経過と、湿疹による低親和性、高親和性の抗原特異的IgE抗体の形成
• タイトル（掲載誌）: Immunity, Inflammation and Disease
• 授与機関名: 徳島大学
• 授与年月日: 2020-01-23
• 授与年月日（W3CDTF）: 2020-01-23
• 報告番号: 甲第3345号
• 学位: 博士（医学）
• 博論授与番号: 甲第3345号
• 本文の言語コード: eng
• 件名標目: allergen microarray; eczema; food allergy; high‐affinity immunoglobulin E; immunoglobulin isotype formation; low‐affinity immunoglobulin E
• 対象利用者: 一般
• 一般注記: Introduction: Allergen‐specific immunoglobulin isotype formation associated with immunoglobulin class‐switching during the lactation period is the immunological background for food allergy in infants. We analyzed the serial changes in the production of feeding type‐related egg‐ and milk‐specific immunoglobulin isotypes from birth to 6 months of age with or without eczema in 84 infants.Methods: Allergen‐specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, IgA, and IgE levels of hen’s egg and bovine milk were measured in cord blood and blood samples from infants at 2, 4, and 6 months of age by the densely carboxylated protein microarray.Results: Formula and mixed feeding were associated with a rapid increase in cow’s milk allergen‐specific immunoglobulins and feeding type‐related significant differences in casein‐specific immunoglobulin levels were detected. Breast and mixed feeding were associated with slow but significant increase in ovalbumin‐specific IgG1 and IgE levels, but not other immunoglobulins. We found two different immunoglobulin isotype formation at 6 months of age with low‐ or high‐affinity IgE against ovalbumin. One isotype formation pattern had relatively high ovalbumin‐specific IgG1 levels, detectable IgG2, and low‐affinity IgE, while the other had low ovalbumin‐specific IgG1 levels, undetectable IgG2, and high levels of high‐affinity IgE. The incidence of eczema was significantly higher in the latter pattern (84.6%), compared with the remaining infants (42.2%).Conclusions: Feeding practice‐related allergen sensitization and immunoglobulin isotype formation were identified during the lactation period. The development of eczema during the lactation period could potentially modify the immunoglobulin isotype formation with high levels of high‐affinity IgE.
• DOI: info:doi/10.1002/iid3.245; https://doi.org/info:doi/10.1002/iid3.245
• 国立国会図書館永続的識別子: info:ndljp/pid/11458303; https://dl.ndl.go.jp/pid/11458303
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2020-03-11T23:38:06+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://repo.lib.tokushima-u.ac.jp/114285
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp