並列タイトル等腎臓の発達過程である新生児においてアンジオテンシノーゲンの発現は増強している
Angiotensinogen expression in neonates
タイトル（掲載誌）Clinical and Experimental Nephrology
一般注記BackgroundWe recently demonstrated that preterm neonates have higher urinary angiotensinogen (AGT) levels than full-term neonates. Here, we tested the hypothesis that enhanced neonatal AGT expression is associated with intrarenal renin-angiotensin system (RAS) status during kidney development.MethodsWe prospectively recruited neonates born at our hospital and healthy children with minor glomerular abnormalities between April 2013 and March 2017. We measured neonatal plasma and urinary AGT levels at birth and one year later and assessed renal AGT expression in kidney tissues from neonates and healthy children using immunohistochemical (IHC) analysis.ResultsFifty-four neonates and eight children were enrolled. Although there were no changes in plasma AGT levels, urinary AGT levels were significantly decreased one year after birth. Urinary AGT levels at birth were inversely correlated with gestational age, and urinary AGT levels at birth and one year later were inversely correlated with estimated glomerular filtration rate one year after birth. IHC analysis showed that renal AGT expression in neonates was higher than that in healthy children and inversely correlated with gestational age.ConclusionsEnhanced AGT expression and urinary AGT excretion may reflect intrarenal RAS activation associated with kidney development in utero.
DOIinfo:doi/10.1007/s10157-018-1662-3
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受理日（W3CDTF）2020-07-06T20:31:19+09:00
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