In vitro effects of febrifugine on Schistosoma mansoni adult worms

• 資料種別: 記事
• タイトル: In vitro effects of febrifugine on Schistosoma mansoni adult worms
• 著者・編者: Yoshinori Mitsui; Mitsumasa Miura; Kentaro Kato
• 出版事項: 日本 : Springer Nature
• 出版年月日等: 2020-06-04
• 出版年（W3CDTF）: 2020-06-04
• タイトル（掲載誌）: Tropical medicine and health
• 巻号年月日等（掲載誌）: 48(42)
• 掲載巻: 48(42)
• ISSN（掲載誌）: 1349-4147
• ISSN-L（掲載誌）: 1348-8945
• 本文の言語コード: eng
• DOI: 10.1186/s41182-020-00230-x; https://doi.org/10.1186/s41182-020-00230-x
• 国立国会図書館永続的識別子: info:ndljp/pid/11520449; https://dl.ndl.go.jp/pid/11520449
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• 収集根拠: オンライン資料収集制度
• 受理日（W3CDTF）: 2020-08-03T12:00:21+09:00
• 保存日（W3CDTF）: 2020-08-03
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://tropmedhealth.biomedcentral.com/articles
• 掲載誌（国立国会図書館永続的識別子）: info:ndljp/pid/11467623; https://dl.ndl.go.jp/pid/11467623
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• 要約等: Background: Reports on the antischistosomal effect of several antimalarial drugs such as artesunate, mefloquine, and amodiaquine suggest that febrifugine, which exerts an antimalarial effect, can also be expected to possess antischistosomal potential. The present study investigates the antischistosomal effects of febrifugine. Methods: In experiment 1, Schistosoma mansoni adult worm pairs were incubated in a medium alone as a control or supplemented with febrifugine at 0.05, 0.1, 0.2, and 0.5 μg/ml for 14 days. The morphology of the worms and the egg production of the female worms were observed simultaneously. In experiment 2, the incubation was conducted as in experiment 1, except that the febrifugine concentrations were reduced to 0.005, 0.01, and 0.02 μg/ml. In addition, S. mansoni adult worms were incubated with either 0.5 μg/ml febrifugine or none as a control for 5 days and stained with neutral red dye. Results: Febrifugine significantly reduced the survival of S. mansoni male and female worms at concentrations of 0.02-0.5 μg/ml following incubation for 14 days and remarkably inhibited the daily egg output of the female worms. The non-treated male and female worms remained morphologically normal within the period of 14 days, whereas male and female worms treated with febrifugine at different concentrations gradually twisted and subsequently died. In addition, S. mansoni adult worms were incubated with either 0.5 μg/ml febrifugine or none as a control for 5 days and stained with neutral red dye. Non-treated male worms were morphologically normal and stained dark red with neutral red, while febrifugine-treated male worms appeared similar to those in the control group and were stained at a slightly lower level of dark red than the non-treated male worms. Non-treated female worms were morphologically normal, and their intestinal tract and vitellaria were stained deep red and dark red, respectively. In contrast, febrifugine-treated female worms were morphologically damaged, and their intestinal tract and vitellaria remained mostly unstained and stained dark red, respectively. Conclusion: Febrifugine exerts potent antischistosomal effects and can be expected to contribute to the development of a novel antischistosomal drug.; Tropical Medicine and Health, 48(1), art.no.42; 2020
• DOI: 10.1186/s41182-020-00230-x; https://doi.org/10.1186/s41182-020-00230-x
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: c The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence,visit http://creativecommons.org/licenses/by/4.0/.
• 関連情報（URI）: http://hdl.handle.net/10069/40132; https://nagasaki-u.repo.nii.ac.jp/records/938; http://id.ndl.go.jp/digimeta/11520449; https://dl.ndl.go.jp/pid/11520449; https://search.jamas.or.jp/link/ui/2022060628
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: 学術機関リポジトリデータベース; https://irdb.nii.ac.jp; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; CiNii Articles
• 書誌ID（NDLBibID）: 11520449; http://id.ndl.go.jp/bib/11520449
• NII論文ID: 120006988140