Overexpression of Antiapoptotic MCL-1 Predicts Worse Overall Survival of Patients With Non-small Cell Lung Cancer

• 資料種別: 博士論文
• タイトル: Overexpression of Antiapoptotic MCL-1 Predicts Worse Overall Survival of Patients With Non-small Cell Lung Cancer
• 著者・編者: 中野, 貴之
• 著者標目: 中野, 貴之
• 出版年月日等: 2020-06-25
• 出版年（W3CDTF）: 2020-06-25
• 並列タイトル等: 抗アポトーシス因子MCL-1の高発現は非小細胞肺癌患者の予後不良を予測する
• 授与機関名: 香川大学
• 授与年月日: 2020-06-25
• 授与年月日（W3CDTF）: 2020-06-25
• 報告番号: 甲第749号
• 学位: 博士（医学）
• 博論授与番号: 甲第749号
• 本文の言語コード: eng
• 著者別名: Nakano, Takayuki
• 件名標目: Apoptosis; myeloid cell leukemia-1; non-small cell lung cancer; prognosis; survival
• 対象利用者: 一般
• 一般注記: Background/Aim: Myeloid cell leukemia-1 (MCL-1) is a member of the B-cell lymphoma-2 (Bcl-2) family of proteins, which regulate the intrinsic (mitochondrial) apoptotic cascade. MCL-1 inhibits apoptosis, which may be associated with resistance to cancer therapy. Therefore, in this study, the clinical role of MCL-1 in non-small cell lung cancer (NSCLC) was explored. Patients and Methods: This retrospective study included 80 patients with stage 1-3A NSCLC, who underwent surgery without preoperative treatment between 2010 and 2011. MCL-1 expression and Ki-67 index were determined via immunohistochemical staining. Apoptotic index (AI) was determined via terminal deoxynucleotidyl transferase dUTP nick end labeling. Results: The receiver operating characteristic curve analysis (area under curve=0.6785) revealed that MCL-1 expression in 30.0% of the NSCLC tumor cells was a significant cut-off for predicting prognosis. Tumors were considered MCL-1-positive if staining was observed in >30% of the cells. Thirty-six tumors (45.0%) were MCL-1-positive. However, there were no significant differences between MCL-1 expression and clinical variables. AI was lower in MCL-1-positive (2.2±3.6%) than in MCL-1-negative (5.2±7.9%) tumors, although the difference was not significant (p=0.1080). The Ki-67 index was significantly higher in MCL-1-positive than in MCL-1-negative tumors (18.0% vs. 3.0%; p<0.001). Five-year survival rate was significantly worse in patients with MCL-1-positive tumors (68.3%) than in those with MCL-1-negative tumors (93.1%, p=0.0057). Univariate [hazard ratio (HR)=5.041, p=0.0013], and multivariate analyses revealed that MCL-1 expression was a significant prognostic factor (HR=3.983, p=0.0411). Conclusion: MCL-1 expression in NSCLC cells correlated inversely with AI and positively with Ki-67 index. MCL-1 may serve as a potential prognostic biomarker and a novel therapeutic target in NSCLC.; This is the Publisher's Version of the following article: Overexpression of Antiapoptotic MCL-1 Predicts Worse Overall Survival of Patients With Non-small Cell Lung Cancer; Anticancer Research; Volume 40 Number 2 (2020) Pages: 1007-1014; doi:10.21873/anticanres.14035, which has been published in final form at https://doi.org/10.21873/anticanres.14035.
• DOI: info:doi/10.21873/anticanres.14035; https://doi.org/info:doi/10.21873/anticanres.14035
• 国立国会図書館永続的識別子: info:ndljp/pid/11526073; https://dl.ndl.go.jp/pid/11526073
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2020-08-11T22:41:34+09:00
• 作成日（W3CDTF）: 2020-10-09
• 記録形式（IMT）: PDF
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 関連情報: This is the Publisher's Version of the following article: Overexpression of Antiapoptotic MCL-1 Predicts Worse Overall Survival of Patients With Non-small Cell Lung Cancer; Anticancer Research; Volume 40 Number 2 (2020) Pages: 1007-1014; doi:10.21873/anticanres.14035, which has been published in final form at https://doi.org/10.21873/anticanres.14035.
• 掲載誌（URI）: https://kagawa-u.repo.nii.ac.jp/records/145
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp