並列タイトル等脊髄前角運動ニューロンのシナプス伝達および細胞興奮性に対するノルアドレナリンの作用機序
一般注記Noradrenaline (NA) modulates the spinal motor networks for locomotion and facilitates neuroplasticity, possibly assisting neuronal network activation and neuroplasticity in the recovery phase of spinal cord injuries. However, neither the effects nor the mechanisms of NA on synaptic transmission and neuronal excitability in spinal ventral horn (VH) neurons are well characterized, especially in rats aged 7 postnatal days or older. To gain insight into NA regulation of VH neuronal activity, we used a whole-cell patch-clamp approach in late neonatal rats (postnatal day 7–15). In voltage-clamp recordings at −70 mV, NA increased the frequency and amplitude of excitatory postsynaptic currents via the activation of somatic α_1- and β-adrenoceptors of presynaptic neurons. Moreover, NA induced an inward current through the activation of postsynapticα_1- and β-adrenoceptors. At a holding potential of 0 mV, NA also increased frequency and amplitude of both GABAergic and glycinergic inhibitory postsynaptic currents via the activation of somatic adrenoceptors in presynaptic neurons. In current-clamp recordings, NA depolarized resting membrane potentials and increased the firing frequency of action potentials in VH neurons, indicating that it enhances the excitability of these neurons. Our findings provide new insights that establish NA-based pharmacological therapy as an effective method to activate neuronal networks of the spinal VH in the recovery phase of spinal cord injuries.
Neuroscience. 2019, 408, 161-176.
新大院博(医)甲第895号
元資料の権利情報 : 【○!C】 2019 IBRO. Published by Elsevier Ltd. All rights reserved.
DOIinfo:doi/10.1016/j.neuroscience.2019.03.026
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