Intermittent administration of parathyroid hormone improves bone quality and quantity around implants in rat tibiae

• 資料種別: 博士論文
• ISSN: 1349-0079
• タイトル: Intermittent administration of parathyroid hormone improves bone quality and quantity around implants in rat tibiae
• 巻次・部編番号: 62 2
• 著者・編者: 内田, 悠介
• 著者標目: 内田, 悠介
• 出版事項: 歯科基礎医学会
• 出版年月日等: 2020-06-03
• 出版年（W3CDTF）: 2020-06-03
• 並列タイトル等: PTHの間歇的投与がラット脛骨に埋入されたインプラント周囲の骨量と骨質に与える影響
• タイトル（掲載誌）: Journal of Oral Biosciences
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2020-06-03
• 授与年月日（W3CDTF）: 2020-06-03
• 報告番号: 甲医歯薬第1258号
• 学位: 博士(歯学)
• 博論授与番号: 甲医歯薬第1258号
• 本文の言語コード: eng
• 件名標目: Bone quality; Bone cells; Parathyroid hormone; Implant
• 対象利用者: 一般
• 一般注記: Objectives: Intermittent injection of parathyroid hormone (PTH) is used to treat osteoporosis. The concept of bone quality was updated 20 years ago; however, these updates have not been adopted in implant dentistry. This study aimed to investigate the effects of intermittent administration of PTH on bone quality around implants in rat tibiae. Methods: Grade IV-titanium-threaded implants that were 3.5 mm long and 2.0 mm wide were placed in a randomly selected side of the proximal tibiae of 12-week-old female Wistar rats. Three weeks after implant placement, the rats were randomly divided into PTH-administration and saline-injection groups (PTH and VC, respectively; n = 7 per group). Micro-computed tomographical, histomorphometric, and immunohistochemical analyses were performed to evaluate bone quality and quantity surrounding the implants. Results: PTH significantly increased bone volume and bone mineral density in bones not associated with the implants as compared to these values in the VC group. PTH significantly increased bone area and the amount of collagen within the total inside areas of all implant threads compared to that observed in VC. Moreover, PTH significantly increased the number of osteoblasts, osteocytes, and osteoclasts in the total inside and/or outside areas of all implant threads and altered the ratio of type I and III collagen to total collagen fibers. Conclusions: Within the limitations of this study, intermittent administration of PTH improved both bone quantity and bone quality based on the types and numbers of bone cells and the types of collagen fibers surrounding implants placed into rat tibiae.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1258号 学位授与年月日:令和2年6月3日; Author: Yusuke Uchida, Shinichiro Kuroshima, Yusuke Uto, Riho Kanai, Maaya Inoue, Masayoshi Suzue, Takashi Sawase; Citation: Journal of Oral Biosciences, 62(2), pp.139-146; 2020; identifier:Nagasaki University (長崎大学), 博士(歯学) (2020-06-03); http://hdl.handle.net/10069/40085
• DOI: info:doi/10.1016/j.job.2020.03.001; https://doi.org/info:doi/10.1016/j.job.2020.03.001
• 国立国会図書館永続的識別子: info:ndljp/pid/11538475; https://dl.ndl.go.jp/pid/11538475
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2020-09-07T06:04:08+09:00
• 作成日（W3CDTF）: 2020-12-18
• 記録形式（IMT）: PDF
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 関連情報（URI）: http://hdl.handle.net/10069/40085
• 掲載誌（URI）: http://hdl.handle.net/10069/40219
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

目次

2021-03-07 再収集