並列タイトル等Adherence Starts with Knowledge-12(ASK-12)による日本における低アドヒアランス気管支喘息患者の特徴
一般注記Background: Adherence Starts with Knowledge-12 (ASK-12) is a useful indicator of drug adherence. In this study, we analyzed patient background including social and psychological factors in a low-adherence group of patients with asthma defined using ASK-12. Methods: From a questionnaire survey for patients with asthma from the Niigata Prefecture, Japan, conducted in the fall of 2016, we enrolled patients who answered all ASK-12 items and underwent a measured respiratory function test within 1 year. The low-adherence group (ASK-12 28) was compared with the control group (ASK-12 < 28), and we conducted a cluster analysis of the low-adherence group. Results: There were 170 patients in the low-adherence group and 402 patients in the control group. There was a significant difference between age, gender, working status, smoking history, the percentage of forced expiratory volume in one second (%FEV_1), asthma control test (ACT), and Patient HealthQuestionnaire-9 (PHQ-9). score between the two groups. Logistic analysis revealed that working status (working), % FEV1 (< 90%), and PHQ-9 score (> 5) were independent factors for the low-adherence group. The cluster analysis identified three clusters in the low-adherence group. Among these, one cluster was characterized by elderly males with chronic obstructive pulmonary disease and another by middle-aged nonsmoking females with a depression tendency, had problems with asthma control. Conclusions: Several factors were considered to be attributed to low drug-adherence. There were several phenotypes in the low-adherence population correlated with incomplete asthma control. Intervention with drug adherence should be a future goal for asthma treatment.
Allergology International. 2020, 69(1), 61-65.
新大院博(医)甲第923号
元資料の権利情報 : 【○!C】 2019, Japanese Society of Allergology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
DOIinfo:doi/10.1016/j.alit.2019.07.006
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