Reduced prefrontal hemodynamic response in adult attention-deficit hyperactivity disorder as measured by near-infrared spectroscopy.

• 資料種別: 博士論文
• ISSN: 1323-1316
• タイトル: Reduced prefrontal hemodynamic response in adult attention-deficit hyperactivity disorder as measured by near-infrared spectroscopy.
• 巻次・部編番号: 72 6
• 著者・編者: Ueda, Shotaro; Ota, Toyosaku; Iida, Junzo; Yamamoto, Kazuhiko; Yoshino, Hiroki; Kishimoto, Naoko; Kishimoto, Toshifumi
• 著者標目: Ueda, Shotaro; Ota, Toyosaku; Iida, Junzo; Yamamoto, Kazuhiko; Yoshino, Hiroki; Kishimoto, Naoko; Kishimoto, Toshifumi
• 出版事項: Japanese Society of Psychiatry and Neurology / John Wiley & Sons, Inc.
• 出版年月日等: 2018-06; 72 6
• 出版年（W3CDTF）: 2018-06
• 並列タイトル等: 近赤外線スペクトロスコピィを用いた成人期注意欠如・多動症の前頭前野における血液動態反応の低下
• タイトル（掲載誌）: Psychiatry and clinical neurosciences
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2018-11-30
• 授与年月日（W3CDTF）: 2018-11-30
• 報告番号: 乙第1422号
• 学位: 博士（医学）
• 博論授与番号: 乙第1422号
• 本文の言語コード: eng
• 件名標目: adult attention-deficit hyperactivity disorder; functional neuroimaging study; near-infrared spectroscopy; prefrontal hemodynamic response; Stroop Color-Word Task
• 対象利用者: 一般
• 一般注記: type:Thesis; AIM: Recent developments in near-infrared spectroscopy (NIRS) have enabled non-invasive clarification of brain functions in psychiatric disorders. In pediatric attention-deficit hyperactivity disorder (ADHD), reduced prefrontal hemodynamic responses have been observed with NIRS repeatedly. However, there are few studies of adult ADHD by multi-channel NIRS. Therefore, in this study, we used multi-channel NIRS to examine the characteristics of prefrontal hemodynamic responses during the Stroop Color-Word Task (SCWT) in adult ADHD patients and in age- and sex-matched control subjects. METHODS: Twelve treatment-naïve adults with ADHD and 12 age- and sex-matched healthy control subjects participated in the present study after giving consent. We used 24-channel NIRS to measure the oxygenated hemoglobin (oxy-Hb) changes at the frontal lobes of participants during the SCWT. We compared the oxy-Hb changes between adults with ADHD and control subjects by t-tests with Bonferroni correction. RESULTS: During the SCWT, the oxy-Hb changes observed in the ADHD group were significantly smaller than those in the control group in channels 11, 16, 18, 21, 22, 23, and 24, corresponding to the prefrontal cortex. At channels 16, 21, 23, and 24 of the ADHD group, there were negative correlations between the symptomatic severity and the oxy-Hb changes. CONCLUSION: The present study suggests that adults with ADHD have reduced prefrontal hemodynamic response as measured by NIRS.; 博士（医学）・乙第1422号・平成30年11月30日; © 2018 The Authors. Psychiatry and Clinical Neurosciences © 2018 Japanese Society of Psychiatry and Neurology; This is the pre-peer reviewed version of the following article: [https://onlinelibrary.wiley.com/doi/full/10.1111/pcn.12643], which has been published in final form at [https://doi.org/10.1111/pcn.12643]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.; identifier:Psychiatry and clinical neurosciences Vol.72 No.6 p.380-390 (2018 Jun); identifier:13231316; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3505; identifier:Psychiatry and clinical neurosciences, 72(6): 380-390
• DOI: info:doi/10.1111/pcn.12643; https://doi.org/info:doi/10.1111/pcn.12643
• 国立国会図書館永続的識別子: info:ndljp/pid/11538763; https://dl.ndl.go.jp/pid/11538763
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2020-09-07T06:04:08+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/3505
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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