Angiotensin receptor blockade attenuates cholangiocarcinoma cell growth by inhibiting the oncogenic activity of Yes-associated protein.

• 資料種別: 博士論文
• ISSN: 0304-3835
• タイトル: Angiotensin receptor blockade attenuates cholangiocarcinoma cell growth by inhibiting the oncogenic activity of Yes-associated protein.
• 巻次・部編番号: 434
• 著者・編者: Saikawa, Soichiro; Kaji, Kosuke; Nishimura, Norihisa; Seki, Kenichiro; Sato, Shinya; Nakanishi, Keisuke; Kitagawa, Koh; Kawaratani, Hideto; Kitade, Mitsuteru; Moriya, Kei; Namisaki, Tadashi; Mitoro, Akira; Yoshiji, Hitoshi
• 著者標目: Saikawa, Soichiro; Kaji, Kosuke; Nishimura, Norihisa; Seki, Kenichiro; Sato, Shinya; Nakanishi, Keisuke; Kitagawa, Koh; Kawaratani, Hideto; Kitade, Mitsuteru; Moriya, Kei; Namisaki, Tadashi; Mitoro, Akira; Yoshiji, Hitoshi
• 出版事項: Elsevier
• 出版年月日等: 2018-10-10; 434
• 出版年（W3CDTF）: 2018-10-10
• 並列タイトル等: アンギオテンシン受容体を遮断することによりYes関連蛋白質の発癌活性が阻害されて胆管癌細胞増殖が抑制される
• タイトル（掲載誌）: Cancer letters
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2020-03-16
• 授与年月日（W3CDTF）: 2020-03-16
• 報告番号: 甲第728号
• 学位: 博士（医学）
• 博論授与番号: 甲第728号
• 本文の言語コード: eng
• 件名標目: Angiotensin receptor blocker; Cholangiocarcinoma; Yes-associated protein; Angiogenesis; G protein-coupled receptor
• 対象利用者: 一般
• 一般注記: type:Thesis; Cholangiocarcinoma (CCA) is a destructive malignancy with limited responsiveness to conventional chemotherapy. Although angiotensin receptor blockers (ARBs) have gained attention for their potential anticancer activity, little is known about their effects on CCA. The transcriptional co-activator, Yes-associated protein (YAP) is a critical oncogene in several cancers, including CCA. Following recent evidence showing that YAP is regulated by angiotensin II (AT-II), we investigated the effects of an ARB, losartan, on two human CCA cell lines (KKU-M213 and HuCCT-1) with regards to YAP oncogenic regulation. Losartan suppressed AT-II-induced CCA cell proliferation in a dose-dependent manner, induced apoptosis, decreased YAP (Ser127), and downregulated the YAP target genes CTGF, CYR61, ANKRD1, and MFAP5. However, losartan did not affect epithelial-mesenchymal transition, differentiation, or stemness in the CCA cells. Xenograft tumor growth assay showed that oral administration of a low clinical dose of losartan considerably reduced subcutaneous tumor burden and attenuated intratumor vascularization in CCA cell-derived xenograft tumors in BALB/c nude mice. These results indicate that ARB therapy could serve as a potential novel strategy for CCA treatment.; 博士（医学）・甲第728号・令和2年3月16日; Copyright © 2018 Elsevier B.V. All rights reserved.; identifier:Cancer letters Vol.434 p.120-129 (2018 Oct); identifier:03043835; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3719; identifier:Cancer letters, 434: 120-129
• DOI: info:doi/10.1016/j.canlet.2018.07.021; https://doi.org/info:doi/10.1016/j.canlet.2018.07.021
• 国立国会図書館永続的識別子: info:ndljp/pid/11551880; https://dl.ndl.go.jp/pid/11551880
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2020-10-06T21:18:06+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/3719
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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