並列タイトル等本邦の地域在住高齢者における肺炎球菌保菌に関する横断研究
授与機関名Nagasaki University (長崎大学)
一般注記Background: The carriage prevalence of pneumococcus among community-dwelling older adults is not fully understood, especially in superaged societies. Our purpose was to elucidate the carriage prevalence of pneumococcus in the upper respiratory tract among Japanese community-dwelling adults aged ?65 years. Methods: We conducted a cross-sectional study of generally healthy community-dwelling adults aged ?65 years in Nagasaki city, Japan. Demographic and clinical data and nasopharyngeal, oropharyngeal and saliva samples were collected from February 21st, 2018, to December 17th, 2018. The specimens were tested by culture and molecular methods. Results: Among a total of 504 enrolled participants, none were positive for pneumococcus by culture, and 22 were positive by PCR. The overall carriage prevalence was 4.4% (95% CI: 2.8?6.5%). The prevalence was highest in saliva samples, followed by oropharyngeal and nasopharyngeal samples. No demographic characteristics were associated with carriage prevalence, including age (4.7% among participants aged 65?74 years and 4.1% among those 75 years and older). Among the pneumococcal-positive participants, 18.2% were PCV13-covered serotypes. Conclusions: Our data suggest a low carriage prevalence of S. pneumoniae among community-dwelling older people in Japan.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1267号 学位授与年月日:令和2年9月18日
Author: Ikkoh Yasuda, Motoi Suzuki, Bhim Gopal Dhoubhadel, Mayumi Terada, Akira Satoh, Eiichiro Sando, Tomoko Hiraoka, Masaki Kurihara, Nobuo Matsusaka, Fumitaka Kawahara, Koya Ariyoshi, Konosuke Morimoto
Citation: Vaccine, 38(21), pp.3752-3758; 2020
identifier:Nagasaki University (長崎大学), 博士(医学) (2020-09-18)
http://hdl.handle.net/10069/40271
DOIinfo:doi/10.1016/j.vaccine.2020.03.033
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受理日（W3CDTF）2020-10-06T21:18:06+09:00
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