Potential role of the PD-L1 expression and tumor-infiltrating lymphocytes on neuroblastoma.

• 資料種別: 博士論文
• ISSN: 0179-0358
• タイトル: Potential role of the PD-L1 expression and tumor-infiltrating lymphocytes on neuroblastoma.
• 巻次・部編番号: 36 2
• 著者・編者: Zuo, Shogo; Sho, Masayuki; Sawai, Toshio; Kanehiro, Hiromichi; Maeda, Kosaku; Yoshida, Makiko; Tsukada, Ryo; Nomura, Motonari; Okuyama, Hiroomi
• 著者標目: Zuo, Shogo; Sho, Masayuki; Sawai, Toshio; Kanehiro, Hiromichi; Maeda, Kosaku; Yoshida, Makiko; Tsukada, Ryo; Nomura, Motonari; Okuyama, Hiroomi
• 出版事項: Springer Nature
• 出版年月日等: 2020-02; 36 2
• 出版年（W3CDTF）: 2020-02
• 並列タイトル等: 神経芽腫におけるPD-L1発現と腫瘍組織浸潤リンパ球の潜在的役割について
• タイトル（掲載誌）: Pediatric surgery international
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2020-06-30
• 授与年月日（W3CDTF）: 2020-06-30
• 報告番号: 乙第1458号
• 学位: 博士（医学）
• 博論授与番号: 乙第1458号
• 本文の言語コード: eng
• 件名標目: Neuroblastoma; PD-L1; Tumor-infiltrating lymphocytes; Recurrence
• 対象利用者: 一般
• 一般注記: type:Thesis; Purpose: The programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway has garnered much attention for its roles in clinical oncology. The aim of this study was to examine the clinical impact of the PD-L1 expression and tumor-infiltrating lymphocytes (TILs) on neuroblastoma. Methods: We evaluated the PD-L1 expression and TIL status in 31 patients with neuroblastoma who underwent a biopsy or resection by an immunohistochemical analysis. Furthermore, we performed the serial analysis of the PD-L1 status before and after chemotherapy in 15 patients. Results: Among the 31 cases, 11 (35%) showed a positive PD-L1 expression. The survival analysis showed a trend toward an association between PD-L1 positivity and a decreased overall survival. PD-L1 positivity tended to be associated with higher levels of tumor markers. In the serial analysis of the PD-L1 status, positivity was noted in 8 of 15 patients before chemotherapy and 6 after chemotherapy. Notably, all four patients with a positive PD-L1 status both before and after chemotherapy had recurrence, and 3 of them died during the follow-up period. Conclusion: Our findings suggest that the PD-L1 tumor expression might be a good biomarker for the treatment of neuroblastoma patients, especially for advanced neuroblastoma.; 博士（医学）・乙第1458号・令和2年6月30日; © Springer-Verlag GmbH Germany, part of Springer Nature 2020; This is a post-peer-review, pre-copyedit version of an article published in Pediatric surgery international. The final authenticated version is available online at: http://doi.org/10.1007/s00383-019-04616-9.; identifier:Pediatric surgery international Vol.36 No.2 p.137-143 (2020 Feb); identifier:01790358; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3759; identifier:Pediatric surgery international, 36(2): 137-143
• DOI: info:doi/10.1007/s00383-019-04616-9; https://doi.org/info:doi/10.1007/s00383-019-04616-9
• 国立国会図書館永続的識別子: info:ndljp/pid/11645284; https://dl.ndl.go.jp/pid/11645284
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2021-03-07T02:10:05+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/3759
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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