Non-invasive monitoring of paclitaxel and lenvatinib efficacy against anaplastic thyroid cancer in orthotopic SCID mouse models using small-animal FDG-PET/CT

• 資料種別: 博士論文
• ISSN: 1021-335X
• タイトル: Non-invasive monitoring of paclitaxel and lenvatinib efficacy against anaplastic thyroid cancer in orthotopic SCID mouse models using small-animal FDG-PET/CT
• 巻次・部編番号: 44 4
• 著者・編者: Aoyama, Mariko; Takizawa, Hiromitsu; Otani, Tamaki; Inoue, Seiya; Kawakita, Naoya; Tsuboi, Mitsuhiro; Bando, Yoshimi; Uehara, Hisanori; Kondo, Kazuya; Tangoku, Akira
• 著者標目: Aoyama, Mariko; Takizawa, Hiromitsu; Otani, Tamaki; Inoue, Seiya; Kawakita, Naoya; Tsuboi, Mitsuhiro; Bando, Yoshimi; Uehara, Hisanori; Kondo, Kazuya; Tangoku, Akira
• 出版事項: Spandidos Publications
• 出版年月日等: 2020-08-07
• 出版年（W3CDTF）: 2020-08-07
• 並列タイトル等: 甲状腺未分化癌同所移植SCIDマウスモデルへのパクリタキセルとレンバチニブの有効性に対する小動物用FDG-PET/CTを用いた非侵襲的モニタリング; MONITORING ANAPLASTIC THYROID CANCER MODELS BY PET/CT
• タイトル（掲載誌）: Oncology Reports
• 授与機関名: 徳島大学
• 授与年月日: 2020-09-24
• 授与年月日（W3CDTF）: 2020-09-24
• 報告番号: 甲第3461号
• 学位: 博士（医学）
• 博論授与番号: 甲第3461号
• 本文の言語コード: eng
• 件名標目: anaplastic thyroid carcinoma; orthotopic model; 18F-FDG PET/CT; paclitaxel; lenvatinib
• 対象利用者: 一般
• 一般注記: Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid carcinoma with a poor prognosis. Thus, suitable preclinical tumor models are required for the development of new ATC therapies. In the present study, orthotopic tumor xenograft models were established using ATC cell lines and SCID mice, and tumor invasion and the effects of anticancer drugs were evaluated using positron emission tomography/computed tomography (PET/CT) to repeatedly and non-invasively monitor these models. Three ATC cell lines (8305c, 8505c, and ACT-1) were used. Their sensitivities to two anticancer drugs (paclitaxel and lenvatinib) were investigated. The 8505c cell line was orthotopically implanted into SCID mice, which were then divided into three groups: no chemotherapy, paclitaxel (5 mg/kg, administered intraperitoneally, every week), and lenvatinib (5 mg/kg, oral route, every day) groups. PET/CT was performed and tumor growth and the effects of anticancer drugs based on tumor volume and fludeoxyglucose (FDG) uptake were evaluated. 8505c cells exhibited the highest sensitivity to the anticancer drugs. In mice implanted with 8505c cells, continuous increases in FDG uptake associated with tumor growth were detected on PET/CT in the group that received no chemotherapy. The tumor volume and FDG uptake increased by 91.5- and 2.4-fold, respectively, within 2 weeks. The increase observed in tumor volume was 26.9- and 12.2-fold in the paclitaxel and lenvatinib groups, respectively, within 2 weeks. Furthermore, the increase in FDG uptake was 1.8-fold and 1.6-fold in the paclitaxel and lenvatinib groups, respectively, within 2 weeks. In our orthotopic SCID mouse model, tumor growth and the effects of anticancer drugs were repeatedly and non-invasively monitored using PET/CT. The present method is useful for the development of new ATC treatments.
• DOI: info:doi/10.3892/or.2020.7720; https://doi.org/info:doi/10.3892/or.2020.7720
• 国立国会図書館永続的識別子: info:ndljp/pid/11645328; https://dl.ndl.go.jp/pid/11645328
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2021-03-07T02:10:05+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/115331
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp