並列タイトル等成人期自閉スペクトラム症における逆境的小児期体験の事象関連電位への影響
一般注記type:Thesis
Childhood maltreatment is defined as experiencing of physical, emotional and sexual abuse and neglect in childhood. Maltreatment in childhood leads to substantial psychosocial problems later in life in the general population. Individuals with autism spectrum disorder (ASD) have a higher risk of experiencing stressful and traumatic events, such as maltreatment, during childhood. Although childhood maltreatment reportedly leads to psychosocial problems in adults with ASD, the biological associations between childhood experiences and brain function in this population remain understudied. Here, we evaluated the relationships between childhood experiences and event-related potential (ERP) components during the auditory odd-ball task in adults with ASD (N = 21) and typically developed (TD) individuals (N = 22). We found that the higher the severity of sexual abuse, the larger the amplitude of P300 at Fz, Cz, C3, and C4 in individuals with ASD. Conversely, the severity of child maltreatment was associated with P300 latency at Cz and C3 in TD individuals. Moreover, full IQ was significantly associated with the MMN amplitude at Fz, Cz, C3, and C4 in TD individuals. These findings provide the first evidence that ERPs could be used to study the impacts childhood experiences on the brain of individuals with ASD and that childhood sexual abuse has salient impacts on brain function in this population.
博士（医学）・甲第762号・令和2年12月24日
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identifier:Scientific reports Vol.10 No.1 Article No.13447 (2020 Aug)
identifier:20452322
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3820
identifier:Scientific reports, 10(1): Article No.13447
DOIinfo:doi/10.1038/s41598-020-70409-z
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