Reproducibility and Variability of Quantitative Cerebral Blood Flow Measured by Multi-delay 3D Arterial Spin Labeling According to Sex and Menstrual Cycle

• 資料種別: 博士論文
• ISSN: 1349-6867
• タイトル: Reproducibility and Variability of Quantitative Cerebral Blood Flow Measured by Multi-delay 3D Arterial Spin Labeling According to Sex and Menstrual Cycle
• 巻次・部編番号: 67 3-4
• 著者・編者: Otomo, Maki; Harada, Masafumi; Abe, Takashi; Matsumoto, Yuki; Abe, Yumi; Kanazawa, Yuki; Miyoshi, Mitsuharu; Kabasawa, Hiroyuki; Takahashi, Yoshitake
• 著者標目: Otomo, Maki; Harada, Masafumi; Abe, Takashi; Matsumoto, Yuki; Abe, Yumi; Kanazawa, Yuki; Miyoshi, Mitsuharu; Kabasawa, Hiroyuki; Takahashi, Yoshitake
• 出版事項: Tokushima University Faculty of Medicine
• 出版年月日等: 2020-08
• 出版年（W3CDTF）: 2020-08
• 並列タイトル等: 多重遅延3D動脈スピン標識法で測定した定量的脳血流の再現性および性別および月経周期の違いによる変動性について; Reproducibility of CBF using pCASL
• タイトル（掲載誌）: The Journal of Medical Investigation
• 授与機関名: 徳島大学
• 授与年月日: 2020-09-10
• 授与年月日（W3CDTF）: 2020-09-10
• 報告番号: 甲第3433号
• 学位: 博士（医学）
• 博論授与番号: 甲第3433号
• 本文の言語コード: eng
• 件名標目: neuroimaging; arterial spin labeling (ASL); cerebral blood flow (CBF); 3DSRT; gender difference
• 対象利用者: 一般
• 一般注記: Purpose : To determine the reproducibility of corrected quantitative cerebral blood flow (qCBF) through measurement of transit flow time using multi-delay three-dimensional pseudo-continuous arterial spin labeling (pCASL) in healthy men and women and to evaluate the differences in qCBF between not only men and women, but also the follicular and luteal phases of the women’s menstrual cycle. Methods : The participants were 16 healthy volunteers (8 men and 8 women ; mean age, 25.3 years). Two MRI were conducted for all participants ; female participants were conducted in the follicular and luteal phases. The reproducibility of qCBF values was evaluated by the intraclass correlation coefficient (ICC) and differences between the two groups were estimated by voxel-based morphometry (VBM) analysis. Results : The qCBF values were lower in men than in women, and those in females were significantly different between the follicular and luteal phases (P < 0.05). In VBM analysis, the qCBF values of the lower frontal lobes were significantly higher in women than in men (P < 0.05). The qCBF values of the frontal pole were significantly higher in the follicular phase than in the luteal phase (P < 0.01). Conclusion : Multi-delay pCASL can reveal physiological and sex differences in cerebral perfusion.
• DOI: info:doi/10.2152/jmi.67.321; https://doi.org/info:doi/10.2152/jmi.67.321
• 国立国会図書館永続的識別子: info:ndljp/pid/11675776; https://dl.ndl.go.jp/pid/11675776
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2021-05-30T17:29:36+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/115293
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp