Urinary adiponectin excretion is an early predictive marker of the decline of the renal function in patients with diabetes mellitus 4

• 資料種別: 博士論文
• ISSN: 1056-8727
• タイトル: Urinary adiponectin excretion is an early predictive marker of the decline of the renal function in patients with diabetes mellitus
• 巻次・部編番号: 35 4
• 著者・編者: Ishizu, Masashi; Mori, Hiroyasu; Ohishi, Mami; Kuroda, Akio; Akehi, Yuko; Yoshida, Sumiko; Aihara, Ken-ichi; Aiba, Motohiro; Kawano, Tomoharu; Hashida, Seiichi; Matsuhisa, Munehide
• 著者標目: Ishizu, Masashi; Mori, Hiroyasu; Ohishi, Mami; Kuroda, Akio; Akehi, Yuko; Yoshida, Sumiko; Aihara, Ken-ichi; Aiba, Motohiro; Kawano, Tomoharu; Hashida, Seiichi; Matsuhisa, Munehide
• 出版事項: Elsevier
• 出版年月日等: 2021-01-07
• 出版年（W3CDTF）: 2021-01-07
• 並列タイトル等: 尿中アディポネクチン排泄は糖尿病患者における腎機能低下の早期予測指標である。; Urinary adiponectin in DKD
• タイトル（掲載誌）: Journal of Diabetes and its Complications
• 授与機関名: 徳島大学
• 授与年月日: 2021-03-23
• 授与年月日（W3CDTF）: 2021-03-23
• 報告番号: 甲第3503号
• 学位: 博士（医学）
• 博論授与番号: 甲第3503号
• 本文の言語コード: eng
• 件名標目: diabetes kidney disease; urinary adiponectin; estimated glomerular filtration rate
• 対象利用者: 一般
• 一般注記: Aims: Since diabetes-associated kidney complication changes from diabetic nephropathy to diabetic kidney disease (DKD), more suitable biomarkers than urinary albumin are required. It has been hypothesized that urinary adiponectin (u-ADPN) is associated with the progression of DKD. We therefore evaluated the effectiveness of u-ADPN in predicting the decline of the renal function in patients with diabetes prior to end-stage renal disease.Methods: An ultrasensitive immune complex transfer enzyme immunoassay (ICT-EIA) was used to measure total and high molecular weight (HMW) adiponectin separately. We evaluated the relationships between the creatinine-adjusted urinary total-ADPN and HMW-ADPN, albumin (UACR) and liver-type fatty acid binding protein (L-FABP) at baseline and the 2-year change of the estimated glomerular filtration rate (ΔeGFR).Results: This 2-year prospective observational study included 201 patients with diabetes. These patients were divided into three groups according to their ΔeGFR: ≤-10 ml/min/1.73m2, >-10 and ≤0 ml/min/1.73m2, and >0 ml/min/1.73m2. Jonckheere-Terpstra test showed that lower ΔeGFR was associated with higher u-HMW-ADPN (p = 0.045). In logistic regression analysis, u-HMW-ADPN was associated with ΔeGFR after adjusted age, sex, and basal eGFR.Conclusion: Urinary HMW-ADPN could predict a declining renal function in patients with diabetes.
• DOI: info:doi/10.1016/j.jdiacomp.2021.107848; https://doi.org/info:doi/10.1016/j.jdiacomp.2021.107848
• 国立国会図書館永続的識別子: info:ndljp/pid/11692595; https://dl.ndl.go.jp/pid/11692595
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2021-07-05T22:24:43+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/115675
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp