Antiglycative effect of black galangal, Kaempferia parviflora Wall. Ex. Baker (Zingiberaceae)

• 資料種別: 記事
• タイトル: Antiglycative effect of black galangal, Kaempferia parviflora Wall. Ex. Baker (Zingiberaceae)
• 著者・編者: Masayuki Yagi; Kayoko Inoue; Yasuo Sato
• 出版事項: 日本 : 糖化ストレス研究会
• 出版年月日等: 2021-03-31
• 出版年（W3CDTF）: 2021-03-31
• 並列タイトル等: 黒ガリンガルの抗糖化作用
• タイトル（掲載誌）: Glycative stress research
• 巻号年月日等（掲載誌）: 8(1)
• 掲載巻: 8(1)
• ISSN（掲載誌）: 2188-3610
• ISSN-L（掲載誌）: 2188-3610
• 本文の言語コード: eng; jpn
• DOI: 10.24659/gsr.8.1_1; https://doi.org/10.24659/gsr.8.1_1
• 国立国会図書館永続的識別子: info:ndljp/pid/11703334; https://dl.ndl.go.jp/pid/11703334
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• 収集根拠: オンライン資料収集制度
• 受理日（W3CDTF）: 2021-07-14T21:40:34+09:00
• 保存日（W3CDTF）: 2021-05-23
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://www.toukastress.jp/webj/
• 掲載誌（国立国会図書館永続的識別子）: info:ndljp/pid/11703333; https://dl.ndl.go.jp/pid/11703333
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• 要約等: Accumulation of advanced glycation endproducts (AGEs) in the body due to glycative stress is a factor in the onset of aging and lifestyle-related diseases. Suppression of glycative stress in the body is called anti-glycation, and includes suppression of postprandial hyperglycemia, suppression of glycative reaction, and decomposition and excretion of AGEs. It is already known that plant materials, i.e., vegetables and herbs, have an anti-glycative effect. Of these, the rhizome of black galangal (Kaempferia parviflora Wall. Ex. Baker; KP), which is a type of ginger family plant (Zingiberaceae), has an action of suppressing the formation of fluorescent AGEs, and polymethoxy flavonoids (PMF); and hydrophilic components are thought to be involved as the active components. In this study, for the purpose of further verifying the possibility of KP as an anti-glycation material, we focused on the hydrophilic component in the KP rhizome and evaluated the anti-glycative effect and AGE decomposition action. As a sample, a hot water (80°C) extract of dry KP rhizome was used. The anti-glycative effect of the KP extract was examined for actions of inhibiting the formation of AGEs and intermediates in the human serum albumin (HSA)-glucose glycation model. Regarding the degrading action of AGEs, the cleaving action of AGE cross-links and the enhancing action of oxidized protein hydrolase (OPH) activity. In the results, the KP extracts inhibited the formation of fluorescent AGEs, pentosidine, CML (Nε-carboxymethyllysine) and intermediates, 3-deoxyglucosone (3DG), glyoxal solution (GO) and methylglyoxal solution (MGO). For the decomposition effect, the KP extract enhanced actions of both cross-link cleaving of AGEs and OPH activity. In conclusion, it is indicated that KP, as an anti-glycative material, can suppress the production of many types of AGEs with different pathways and acts on the decomposition of AGEs, thus reducing the amount of accumulated AGEs in the body.
• DOI: 10.24659/gsr.8.1_1
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: Accumulation of advanced glycation endproducts (AGEs) in the body due to glycative stress is a factor in the onset of aging and lifestyle-related diseases. Suppression of glycative stress in the body is called anti-glycation, and includes suppression of postprandial hyperglycemia, suppression of glycative reaction, and decomposition and excretion of AGEs. It is already known that plant materials, i.e., vegetables and herbs, have an anti-glycative effect. Of these, the rhizome of black galangal (Kaempferia parviflora Wall. Ex. Baker; KP), which is a type of ginger family plant (Zingiberaceae), has an action of suppressing the formation of fluorescent AGEs, and polymethoxy flavonoids (PMF); and hydrophilic components are thought to be involved as the active components. In this study, for the purpose of further verifying the possibility of KP as an anti-glycation material, we focused on the hydrophilic component in the KP rhizome and evaluated the anti-glycative effect and AGE decomposition action. As a sample, a hot water (80°C) extract of dry KP rhizome was used. The anti-glycative effect of the KP extract was examined for actions of inhibiting the formation of AGEs and intermediates in the human serum albumin (HSA)-glucose glycation model. Regarding the degrading action of AGEs, the cleaving action of AGE cross-links and the enhancing action of oxidized protein hydrolase (OPH) activity. In the results, the KP extracts inhibited the formation of fluorescent AGEs, pentosidine, CML (Nε-carboxymethyllysine) and intermediates, 3-deoxyglucosone (3DG), glyoxal solution (GO) and methylglyoxal solution (MGO). For the decomposition effect, the KP extract enhanced actions of both cross-link cleaving of AGEs and OPH activity. In conclusion, it is indicated that KP, as an anti-glycative material, can suppress the production of many types of AGEs with different pathways and acts on the decomposition of AGEs, thus reducing the amount of accumulated AGEs in the body.
• DOI: 10.24659/gsr.8.1_1; https://doi.org/10.24659/gsr.8.1_1
• 関連情報（URI）: http://id.ndl.go.jp/bib/032133599; https://ndlsearch.ndl.go.jp/books/R000000004-I032133599; http://id.ndl.go.jp/digimeta/11703334; https://dl.ndl.go.jp/pid/11703334; https://search.jamas.or.jp/link/ui/2022048919
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; CiNii Articles
• 書誌ID（NDLBibID）: 032133599; http://id.ndl.go.jp/bib/032133599; 11703334; http://id.ndl.go.jp/bib/11703334
• NII論文ID: 130008046224

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