並列タイトル等Association of risk factors for atherosclerosis, including higb-sensitivity C-reactive protein, with carotid intima-media thickness, plaque score, and pulse wave velocity in a male population
学位博士(医学)
Doctor of Philosophy in Medical Science
一般注記博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Intima-media thickness (IMT), plaque score (PS) and brachial-ankle pulse wave velocity (baPWV) are non-invasive parameters for evaluation of atherosclerosis. There have been no reports investigating the associations between IMT, PS, or baPWV and known risk factors for atherosclerosis in the same participants. This study aimed to compare the contributed risk factors among IMT, PS, and baPWV.We enrolled 3,128 male participants who underwent health checkups. Carotid ultrasonography was used to measure IMT and PS, and baPWV was measured using an automatic device. We analyzed the association between these parameters and risk factors for atherosclerosis including obesity, smoking, alcohol, high blood pressure (BP), impaired fasting glucose (IFG), dyslipidemia (DL), and high-sensitivity C-reactive protein (hs-CRP).Multivariate logistic regression analysis revealed high IMT (>0.9 mm) to be independently associated with high BP. The presence of atherosclerosis (PS>1.1 mm) was independently associated with high BP, IFG, and DL. In addition, advanced atherosclerosis (PS>5.1 mm) showed a significant association with high BP, IFG, DL, log hs-CRP, and smoking. High baPWV (>1,600 cm/sec) was significantly correlated with high BP, IFG, and log hs-CRP. IMT, PS and baPWV are all associated with different risk factors among Japanese male participants. Only high BP was a common risk factor for all three parameters. Furthermore, hs-CRP was associated with advanced atherosclerosis, not but with the presence of atherosclerosis.Satoko Ojima, Takuro Kubozono, Shin Kawasoe, Takeko Kawabata, Masaaki Miyata, Hironori Miyahara, Shigeho Maenohara & Mitsuru OhishiAssociation of risk factors for atherosclerosis, including high-sensitivity C-reactive protein, with carotid intima-media thickness, plaque score, and pulse wave velocity in a male populationHypertension Research volume 43, pages422–430 (2020)https://doi.org/10.1038/s41440-019-0388-2
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受理日（W3CDTF）2021-08-09T17:15:52+09:00
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