Gross appearance of the fetal membrane on the placental surface is associated with histological chorioamnionitis and neonatal respiratory disorders

• 資料種別: 博士論文
• ISSN: 1932-6203
• タイトル: Gross appearance of the fetal membrane on the placental surface is associated with histological chorioamnionitis and neonatal respiratory disorders
• 巻次・部編番号: 15 11
• 著者・編者: 堀越, 義正
• 著者標目: 堀越, 義正
• 出版事項: Public Library of Science (PLoS)
• 出版年月日等: 2020-11-30
• 出版年（W3CDTF）: 2020-11-30
• 並列タイトル等: 卵膜の肉眼的な外観は組織学的絨毛膜羊膜炎および新生児呼吸障害と関連する
• タイトル（掲載誌）: PLOS ONE
• 授与機関名: 浜松医科大学
• 授与年月日: 2021-03-16
• 授与年月日（W3CDTF）: 2021-03-16
• 報告番号: 甲第863号
• 学位: 博士（医学）
• 博論授与番号: 甲第863号
• 本文の言語コード: eng
• 対象利用者: 一般
• 一般注記: doctoral; 医学系研究科; An opaque fetal membrane based on gross appearance is traditionally indicative of histological chorioamnionitis; however, to the best of our knowledge, there is currently no supportive evidence, and its diagnostic efficiency has not yet been scientifically demonstrated. The present study aimed to provide scientific insights into the traditional concept of an opaque fetal membrane based on gross appearance being an indicator of histological chorioamnionitis. We examined the placental pathology after screening of the placental gross appearance and perinatal complications and did not examine uncomplicated deliveries. We investigated the relationship between the presence of an opaque fetal membrane and histological chorioamnionitis (Cohort 1, 571 placentas) or the outcomes of neonates delivered at term (Cohort 2, 409 placentas) at Hamamatsu University School of Medicine between 2010 and 2017. The judgment of a positive opaque fetal membrane based on gross appearance correlated with histological chorioamnionitis (Cohort 1). Its sensitivity and specificity were 66.7 and 89.9%, respectively, while positive and negative predictive values were 86.8 and 73.0%, respectively.The judgment of a positive opaque fetal membrane based on gross appearance significantly correlated with chorioamnionitis-related complications in term newborns after adjustments for confounding factors (OR;1.82 [1.07-3.11], P<0.05) (Cohort 2). A correlation was observed even after adjustments for confounding factors. The present study is the first to demonstrate that the judgment of a positive opaque fetal membrane based on gross appearance correlated with histological chorioamnionitis as well as chorioamnionitis-related complications in newborns delivered at term. The present results provide support for the traditionally-described importance of gross inspections for an opaque fetal membrane soon after birth.
• DOI: info:doi/10.1371/journal.pone.0242579; https://doi.org/info:doi/10.1371/journal.pone.0242579
• 国立国会図書館永続的識別子: info:ndljp/pid/11720309; https://dl.ndl.go.jp/pid/11720309
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2021-09-06T03:11:00+09:00
• 作成日（W3CDTF）: 2021-07-20
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10271/00003872; https://hama-med.repo.nii.ac.jp/records/3746
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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