並列タイトル等日本人女性における骨微細構造の加齢や閉経による変化：高解像度末梢骨用定量的CTを用いた解析
タイトル（掲載誌）Journal of Bone and Mineral Metabolism
授与機関名Nagasaki University (長崎大学)
一般注記Introduction: Second-generation high-resolution peripheral quantitative computed tomography (HR-pQCT) has provide higher quality of bone images with a voxel size of 61 μm, enabling direct measurements of trabecular thickness. In addition to the standard parameters, the non-metric trabecular parameters such as trabecular morphology (plate to rod-like structures), connectivity, and anisotropy can also be analyzed. The purpose of this study is to investigate deterioration of bone microstructure in healthy Japanese women by measuring standard and non-metric parameters using HR-pQCT. Materials and methods: Study participants were 61 healthy Japanese women (31?70 years). The distal radius and tibia were scanned using second-generation HR-pQCT, and microstructures of trabecular and cortical bone were measured. Non-metric trabecular parameters included structure model index (SMI), trabecular bone pattern factor (TBPf), connectivity density (Conn.D), number of nodes (N.Nd/TV), degree of anisotropy (DA), and star volume of marrow space (V*ms). Estimated bone strength was evaluated by micro finite element analysis. Associations between bone microstructure, estimated bone strength, age, and menopause were analyzed. Results: Trabecular number declined with age, and trabecular separation increased. SMI and TBPf increased, Conn.D and N.Nd/TV declined, and V*ms increased. Cortical BMD and thickness declined with age, and porosity increased. Stiffness and failure load decreased with age. Cortical thickness and estimated bone strength were affected by menopause. Cortical thickness was most associated with estimated bone strength. Conclusions: Trabecular and cortical bone microstructure were deteriorated markedly with age. Cortical thickness decreased after menopause and was most related to bone strength. Non-metric parameters give additional information about osteoporotic changes of trabecular bone.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1272号 学位授与年月日:令和2年9月2日
Author: Kazuaki Yokota, Ko Chiba, Narihiro Okazaki, Choko Kondo, Mitsuru Doi, Shuta Yamada, Makoto Era, Yuichiro Nishino, Akihiko Yonekura, Masato Tomita & Makoto Osaki
Citation: Journal of Bone and Mineral Metabolism, Article in Press
identifier:Nagasaki University (長崎大学), 博士(医学) (2020-09-02)
http://hdl.handle.net/10069/40342
DOIinfo:doi/10.1007/s00774-020-01115-z
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