Disabled Homolog 2 (DAB2) Protein in Tumor Microenvironment Correlates with Aggressive Phenotype in Human Urothelial Carcinoma of the Bladder.

• 資料種別: 博士論文
• ISSN: 2075-4418
• タイトル: Disabled Homolog 2 (DAB2) Protein in Tumor Microenvironment Correlates with Aggressive Phenotype in Human Urothelial Carcinoma of the Bladder.
• 巻次・部編番号: 10 1
• 著者・編者: Itami, Yoshitaka; Miyake, Makito; Ohnishi, Sayuri; Tatsumi, Yoshihiro; Gotoh, Daisuke; Hori, Shunta; Morizawa, Yosuke; Iida, Kota; Ohnishi, Kenta; Nakai, Yasushi; Inoue, Takeshi; Anai, Satoshi; Tanaka, Nobumichi; Fujii, Tomomi; Shimada, Keiji; Furuya, Hideki; Khadka, Vedbar S; Deng, Youping; Fujimoto, Kiyohide
• 著者標目: Itami, Yoshitaka; Miyake, Makito; Ohnishi, Sayuri; Tatsumi, Yoshihiro; Gotoh, Daisuke; Hori, Shunta; Morizawa, Yosuke; Iida, Kota; Ohnishi, Kenta; Nakai, Yasushi; Inoue, Takeshi; Anai, Satoshi; Tanaka, Nobumichi; Fujii, Tomomi; Shimada, Keiji; Furuya, Hideki; Khadka, Vedbar S; Deng, Youping; Fujimoto, Kiyohide
• 出版事項: MDPI
• 出版年月日等: 2020-01-20; 10 1
• 出版年（W3CDTF）: 2020-01-20
• 並列タイトル等: 尿路上皮癌微小環境内におけるDisabled Homolog 2 (DAB2) は腫瘍細胞上皮間葉転換を介して遊走能・浸潤能を高める
• タイトル（掲載誌）: Diagnostics
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2021-03-15
• 授与年月日（W3CDTF）: 2021-03-15
• 報告番号: 甲第768号
• 学位: 博士（医学）
• 博論授与番号: 甲第768号
• 本文の言語コード: eng
• 件名標目: DAB2; bladder cancer; epithelial-mesenchymal transition
• 対象利用者: 一般
• 一般注記: type:Thesis; Disabled homolog-2 (DAB2) has been reported to be a tumor suppressor gene. However, a number of contrary studies suggested that DAB2 promotes tumor invasion in urothelial carcinoma of the bladder (UCB). Here, we investigated the clinical role and biological function of DAB2 in human UCB. Immunohistochemical staining analysis for DAB2 was carried out on UCB tissue specimens. DAB2 expression levels were compared with clinicopathological factors. DAB2 was knocked-down by small interfering RNA (siRNA) transfection, and then its effects on cell proliferation, invasion, and migration, and changes to epithelial-mesenchymal transition (EMT)-related proteins were evaluated. In our in vivo assays, tumor-bearing athymic nude mice subcutaneously inoculated with human UCB cells (MGH-U-3 or UM-UC-3) were treated by DAB2-targeting siRNA. Higher expression of DAB2 was associated with higher clinical T category, high tumor grade, and poor oncological outcome. The knock-down of DAB2 decreased both invasion and migration ability and expression of EMT-related proteins. Significant inhibitory effects on tumor growth and invasion were observed in xenograft tumors of UM-UC-3 treated by DAB2-targeting siRNA. Our findings suggested that DAB2 expression was associated with poor prognosis through increased oncogenic properties including tumor proliferation, migration, invasion, and enhancement of EMT in human UCB.; 博士（医学）・甲第768号・令和3年3月15日; © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).; identifier:Diagnostics Vol.10 No.1 Article No.54 (2020 Jan); identifier:20754418; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3892; identifier:Diagnostics, 10(1): Article No.54
• DOI: info:doi/10.3390/diagnostics10010054; https://doi.org/info:doi/10.3390/diagnostics10010054
• 国立国会図書館永続的識別子: info:ndljp/pid/12071088; https://dl.ndl.go.jp/pid/12071088
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2022-02-06T04:33:19+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/3892
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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