Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers 5

• 資料種別: 博士論文
• ISSN: 1347-4820
• タイトル: Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers
• 巻次・部編番号: 84 5
• 著者・編者: Ito, Hiroyuki; Wakatsuki, Tetsuzo; Yamaguchi, Koji; Fukuda, Daiju; Kawabata, Yutaka; Matsuura, Tomomi; Kusunose, Kenya; Ise, Takayuki; Tobiume, Takeshi; Yagi, Shusuke; Yamada, Hirotsugu; Soeki, Takeshi; Tsuruo, Yoshihiro; Sata, Masataka
• 著者標目: Ito, Hiroyuki; Wakatsuki, Tetsuzo; Yamaguchi, Koji; Fukuda, Daiju; Kawabata, Yutaka; Matsuura, Tomomi; Kusunose, Kenya; Ise, Takayuki; Tobiume, Takeshi; Yagi, Shusuke; Yamada, Hirotsugu; Soeki, Takeshi; Tsuruo, Yoshihiro; Sata, Masataka
• 出版事項: Japanese Circulation Society
• 出版年月日等: 2020-04-24
• 出版年（W3CDTF）: 2020-04-24
• 並列タイトル等: 未固定遺体における動脈硬化性冠動脈プラークと冠動脈外膜vasa vasorum及び局所心臓周囲脂肪内炎症との関連; Coronary Plaque and Epicardial Adipose Inflammation
• タイトル（掲載誌）: Circulation Journal
• 授与機関名: 徳島大学
• 授与年月日: 2021-12-23
• 授与年月日（W3CDTF）: 2021-12-23
• 報告番号: 甲第3564号
• 学位: 博士（医学）
• 博論授与番号: 甲第3564号
• 本文の言語コード: eng
• 件名標目: Coronary plaque; Epicardial adipose tissue; Fresh cadaver; Inflammatory molecules; Vasa vasorum
• 対象利用者: 一般
• 一般注記: Background: The coronary adventitia has recently attracted attention as a source of inflammation because it harbors nutrient blood vessels, termed the vasa vasorum (VV). This study assessed the link between local inflammation in adjacent epicardial adipose tissue (EAT) and coronary arterial atherosclerosis in fresh cadavers.Methods and Results: Lesion characteristics in the left anterior descending coronary artery of 10 fresh cadaveric hearts were evaluated using integrated backscatter intravascular ultrasound (IB-IVUS), and the density of the VV and levels of inflammatory molecules from the adjacent EAT were measured for each of the assessed lesions. The lesions were divided into lipid-rich, lipid-moderate, and lipid-poor groups according to percentage lipid volume assessed by IB-IVUS. Higher expression of inflammatory molecules (i.e., vascular endothelial growth factor A [VEGFA] and VEGFB) was observed in adjacent EAT of lipid-rich (n=11) than in lipid-poor (n=11) lesions (7.99±3.37 vs. 0.45±0.85 arbitrary units [AU], respectively, for VEGFA; 0.27±0.15 vs. 0.11±0.07 AU, respectively, for VEGFB; P<0.05). The density of adventitial VV was greater in lipid-rich than lipid-poor lesions (1.50±0.58% vs. 0.88±0.23%; P<0.05).Conclusions: Lipid-rich coronary plaques are associated with adventitial VV and local inflammation in adjacent EAT in fresh cadavers. This study suggests that local inflammation of EAT is associated with coronary plaque progression via the VV.
• DOI: info:doi/10.1253/circj.CJ-19-0914; https://doi.org/info:doi/10.1253/circj.CJ-19-0914
• 国立国会図書館永続的識別子: info:ndljp/pid/12071165; https://dl.ndl.go.jp/pid/12071165
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2022-02-06T04:33:19+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/116640
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp