並列タイトル等セリンプロテアーゼであるトリプシンがRANKL/RANK相互作用に及ぼす影響
一般注記Recent reports suggest that trypsin and the trypsinlike enzyme tryptase modulate the ability of macrophages to polarize to the M2a phenotype. Trypsin also potentiates mono cytes to differentiate into fibrocytes resulting in enhanced wound healing. Because os teoclasts differentiate from monocyte/macrophage lineage cells, the enzymatic activity might also affect osteoclast differentiation. In this study we examined the effect of tryp sin on the ability of the mouse macrophage cell line RAW 264.7 to differentiate into os teoclasts. We found that trypsin treatment of RAW264.7 cells lowers their ability to differ entiate into osteoclasts in response to RANKL. We also found that trypsin treatment low ered the capacity of RANK to bind its cognate ligand RANKL. Therefore, we concluded that the exposure to trypsin or trypsinlike enzymes might affect macrophage polarization to osteoclasts via degradation of the cell surface receptor RANK.
2018年度
コレクション（個別）国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
受理日（W3CDTF）2022-02-06T04:33:19+09:00
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