並列タイトル等Ⅱ型糖尿病モデルラットにおける実験的歯の移動に関する病理組織学的研究
一般注記Although it is thought that orthodontic treatment should be avoided in patients with diabetes mellitus, as the number of these patients increases, treatment may become necessary for some of them. We experimentally moved the teeth using the Waldo method in Goto-Kakizaki (GK) rats, an animal model of type II diabetes. On days 1, 3, 5 and 7 after initiation of tooth movement, we extracted three upper molars and the surrounding periodontal tissue en bloc, and measured the movement distance between the first (M1) and second (M2) molars. We also measured the distance between the dental crowns of the three teeth from the mesial of M1 to the distal of the third molar (M3). Afterward we made histopathologic observations.Although measurements of tooth movement and inter-crown distance from M1 to M3 showed large values on the first day after initiation of the procedure in the control group, these measurements subsequently did not change. Histopathologically, there was dilation of the periodontal ligament capillaries on the tension side on post-procedure day 1 in both the control and experimental groups. On the pressure side, marked capillary dilation was seen on post-procedure day 5 in the controls and post-procedure day 3 in the experimental group. From post-procedure day 3 the course of the collagen fibers was disrupted in the experimental group and the stainability with silver impregnation staining increased compared with the controls. Thus, in the diabetic rats there was decreased metabolic function, blood supply, and ability to form multinucleated giant cells, and the structure of collagen fibers in the connective tissue was changed. The above suggests that time is required for tooth movement in diabetes and that there is a possibility of marked breakdown of periodontal tissue.
2015
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