並列タイトル等インプラント周囲骨欠損の骨再生過程に及ぼす多孔体β- リン酸三カルシウムおよび多孔体ハイドロキシアパタイト骨補填材の影響
一般注記Although artificial materials are preferred over biological bone substitutes because there is no risk of infection, clinical outcomes are less favorable. We histologically investigated the influence on new bone formation of two types of artificial bone substitutes used to fill in experimental bone defects around implants. Nine dogs were used as the experimental animals, the bilateral mandibular, premolars were extracted, and, after a 3-month observation of osseous healing, 4 bone defects with a diameter of 5.0 mm and a depth of 10 mm were prepared in the alveolar bone of the extracted regions in each animal using a trephine bur. Implants were placed in the distal regions of the bone defects, and the animals were divided into 4 groups : Bone defects around the implants were filled with porous hydroxyapatite (HA), autologous bone, β-tricalcium phosphate (β-TCP), or not filled (controls). The wounds were completely closed, and samples were collected 2, 4 and 8 weeks after the implant treatment. Bone mass continuously increased in the β-TCP group, whereas no increase was noted over 8 weeks in the HA group. No significant difference was observed between the β-TCP and control groups. New bone formation was observed earlier in the β-TCP group than in the HA group. Since HA is not absorbed by osteoclasts, the entrance of cells, such as osteoblasts, into the filled material may have been delayed in the HA group, resulting in the delayed formation of new bone, for which a combination with inclusion of autologous bone may be desirable.
2014年度
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受理日（W3CDTF）2022-02-06T04:33:19+09:00
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