並列タイトル等マウスを対象とした咀嚼中の上顎に対する下顎運動の視覚化―再構築した顎顔面3次元モデルと運動解析の統合―
授与機関名Nagasaki University (長崎大学)
一般注記Background: Mastication is one of the most fundamental functions for the conservation of human life. To clarify the pathogenetic mechanism of various oral dysfunctions, the demand for devices for evaluating stomatognathic function has been increasing. The aim of the present study was to develop a system to reconstruct and visualize 3-dimensional (3D) mandibular movements relative to the maxilla, including dynamic transition of occlusal contacts between the upper and lower dentitions during mastication in mice.Methods: First, mandibular movements with six degrees of freedom were measured using a motion capture system comprising two high-speed cameras and four reflective markers. Second, 3D models of maxillofacial structure were reconstructed from micro-computed tomography images. Movement trajectories of anatomical landmark points on the mandible were then reproduced by integrating the kinematic data of mandibular movements with the anatomical data of maxillofacial structures. Lastly, 3D surface images of the upper dentition with the surrounding maxillofacial structures were transferred to each of the motion capture images to reproduce mandibular movements relative to the maxilla. We also performed electromyography (EMG) of masticatory muscles associated with mandibular movements.Results: The developed system could reproduce the 3D movement trajectories of arbitrary points on the mandible, such as incisor, molars and condylar points with high accuracy and could visualize dynamic transitions of occlusal contacts between upper and lower teeth associated with mandibular movements.Conclusions: The proposed system has potential to elucidate the mechanisms underlying motor coordination of masticatory muscles and to clarify their roles during mastication by taking advantage of the capability to record EMG data synchronously with mandibular movements. Such insights will enhance our understanding of the pathogenesis and diagnosis of oral motor disorders by allowing comparisons between normal mice and genetically modified mice with oral behavioral dysfunctions.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1382号 学位授与年月日:令和3年12月1日
Author: Go Yasuda, Emi Moriuchi, Ryo Hamanaka, Ayumi Fujishita, Tomoko Yoshimi, Kana Yamamoto, Kaori Hayashida, Yoshiyuki Koga and Noriaki Yoshida
Citation: BMC Oral Health, 21, art. no. 527; 2021
identifier:Nagasaki University (長崎大学), 博士(歯学) (2021-12-01)
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