並列タイトル等ミャンマー・ヤンゴン市におけるデング3型ウイルス(DENV-3)遺伝子型Iの出現に伴うDENV-3症例の増加、2017年－2019年
授与機関名Nagasaki University (長崎大学)
一般注記Dengue fever, caused by the mosquito-borne dengue virus (DENV), has been endemic in Myanmar since 1970 and it has become a significant public health burden. It is crucial that circulating DENV strains are identified and monitored, and that their transmission efficiency and association with disease severity is understood. In this study, we analyzed DENV-1, DENV-2, DENV-3, and DENV-4 serotypes in 1235 serum samples collected in Myanmar between 2017 and 2019. Whole-genome sequencing of DENV-1–4 demonstrated that most DENV-1–4 strains had been circulating in Myanmar for several years. We also identified the emergence of DENV-3 genotype-I in 2017 samples, which persisted through 2018 and 2019. The emergence of the strain coincided with a period of increased DENV-3 cases and marked changes in the serotype dynamics. Nevertheless, we detected no significant differences between serum viral loads, disease severity, and infection status of individuals infected with different DENV serotypes during the 3-year study. Our results not only identify the spread of a new DENV-3 genotype into Yangon, Myanmar, but also support the importance of DENV evolution in changing the epidemic dynamics in endemic regions.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1369号 学位授与年月日:令和3年9月17日
Author: Aung Min Soe, Mya Myat Ngwe Tun, Takeshi Nabeshima, Theingi Win Myat, Moh Moh Htun, Htin Lin, Nang Sarm Hom, Shingo Inoue, Khine Mya Nwe, Lynn Pa Pa Aye, Mizuki Fukuta, Kyaw Zin Thant, Futoshi Hasebe, Kouichi Morita, Sujan Shresta, Hlaing Myat Thu, Meng Ling Moi
Citation: Viruses, 13(6), 1152; 2021
identifier:Nagasaki University (長崎大学), 博士(医学) (2021-09-17)
http://hdl.handle.net/10069/00040956
DOIinfo:doi/10.3390/v13061152
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