並列タイトル等当院におけるヘロイン依存症者へのbuprenorphineによる解毒治療についての検討
タイトル（掲載誌）Neuropsychopharmacology reports
一般注記type:Thesis
Aim: We assessed the efficacy of buprenorphine replacement taper therapy in a psychiatric hospital in Japan. Methods: Based on the medical records, a retrospective analysis was performed to evaluate the outcomes of buprenorphine replacement taper therapy in 106 subjects with heroin dependence. Results: We found that replacement and taper therapy with buprenorphine could significantly reduce withdrawal symptoms during detoxification. In addition, the completion rate of detoxification was significantly improved and the length of hospital stay was significantly reduced relative to those who received conventional treatment without buprenorphine. However, the readmission rate increased after the introduction of detoxication therapy with buprenorphine. Conclusion: The present findings suggest not only the efficacy and safety of buprenorphine replacement and taper therapy, but also the requirement for maintenance therapy for individuals with heroin dependence.
博士（医学）・乙第1502号・令和3年3月15日
© 2020 The Authors. Neuropsycho pharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Society of NeuropsychoPharmacology.This is an open access article under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
identifier:Neuropsychopharmacology reports Vol.40 No.4 p.376-382 (2020 Dec)
identifier:2574173X
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3928
identifier:Neuropsychopharmacology reports, 40(4): 376-382
DOIinfo:doi/10.1002/npr2.12147
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