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博士論文
国立国会図書館館内限定公開
収録元データベースで確認する
国立国会図書館デジタルコレクション
デジタルデータあり(大阪歯科学会)
Chemopreventive effect of green tea catechin on rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide
- 国立国会図書館永続的識別子
- info:ndljp/pid/12154582
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資料に関する注記
一般注記:
- Oral cancer treatment may have significant adverse effects on the patient's activities of daily living (ADL) and quality of life (QOL). In recent year...
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デジタル
- 資料種別
- 博士論文
- 著者・編者
- 河野, 多香子
- 著者標目
- 出版事項
- 出版年月日等
- 2014-03-07
- 出版年(W3CDTF)
- 2014-03-07
- 並列タイトル等
- 4NQO誘発ラット舌癌に対する緑茶カテキンの化学的予防効果
- 授与機関名
- 大阪歯科大学
- 授与年月日
- 2014-03-07
- 授与年月日(W3CDTF)
- 2014-03-07
- 報告番号
- 甲第724号
- 学位
- 博士(歯学)
- 博論授与番号
- 甲第724号
- 本文の言語コード
- eng
- 対象利用者
- 一般
- 一般注記
- Oral cancer treatment may have significant adverse effects on the patient's activities of daily living (ADL) and quality of life (QOL). In recent years attention has been focused on the use of food for chemoprevention. (-)-Epigallocatechin-3-gallate (EGCG), which accounts for about half of green tea catechins, is not only a strong antioxidant, but has also been reported to possess anti-tumor and carcinogenesis-inhibiting actions. As the oral mucosa comes into direct contact with green tea, its carcinogenesis-inhibiting action may be effective against oral cancer. We investigated the carcinogenesis-inhibiting activity of EGCG in the carcinogenic process in rats with tongue cancer induced by 4-nitroquinoline 1-oxide (4NQO). Sprague-Dawley (SD) rats were given water containing either a 50-ppm aqueous solution of 4NQO to induce tongue cancer or the 4NQO solution together with a 500-ppm aqueous solution of EGCG. A control group was given only distilled water. Macroscopic observations and histopathologic comparisons were made of the back of the tongue at 8, 12, 16, 20 and 24 weeks after the start of administration. The association between activated nuclear factor κB (NF-κB) p65 and IκB kinase α (IKKα) expression and tumor growth in the carcinogenic process was investigated by immunohistochemical staining and immunoblotting. The administration of EGCG not only significantly suppressed the occurrence of epithelial dysplasia and squamous cell carcinoma in rats with 4NQO-induced tongue cancer, but also inhibited the expression of activated (NF-κB) p65 and IKKα (p<0.05). It also decreased the proportion of Ki-67-positive cells, and inhibited cell proliferative activity (p<0.05). Western blotting was performed for these proteins, and the same results were also obtained for their expression via immunostaining. These results suggest that the carcinogenesis-inhibiting action of EGCG is probably due to the inhibition of activated NF-κB p65, and that long-term administration of EGCG may decrease IKKα expression, increasing its activity in suppressing the promotion of carcinogenesis and suppressing multi-step carcinogenesis.2013
- 国立国会図書館永続的識別子
- info:ndljp/pid/12154582
- コレクション(共通)
- コレクション(障害者向け資料:レベル1)
- コレクション(個別)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- 収集根拠
- 博士論文(自動収集)
- 受理日(W3CDTF)
- 2022-03-06T04:54:00+09:00
- 作成日(W3CDTF)
- 2016-06-23
- 記録形式(IMT)
- application/pdf
- オンライン閲覧公開範囲
- 国立国会図書館内限定公開
- デジタル化資料送信
- 図書館・個人送信対象外
- 遠隔複写可否(NDL)
- 可
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館デジタルコレクション