並列タイトル等10cm以上の巨大肝細胞癌に対する、ゼラチンスポンジによる肝動脈塞栓術 (bland TAE) と、Lipiodolと抗癌剤による肝動脈化学塞栓術 (TACE) の併用法の治療効果
タイトル(掲載誌)Minimally invasive therapy and allied technologies.
一般注記type:Thesis
Introduction: To assess the efficacy of combined therapy involving bland transarterial embolization using gelatin sponge particles (bland GS-TAE) followed by transarterial chemoembolization using lipiodol mixed with anticancer agents and GS particles (Lip-TACE) to reduce the adverse events and increase the therapeutic effect of Lip-TACE in the treatment of huge (≥10 cm) hepatocellular carcinoma (HCC).Material and methods: Twenty-one consecutive patients with huge HCCs (≥10 cm in diameter) were enrolled in this study. First, bland GS-TAE was performed to reduce the tumor volume, and then Lip-TACE was performed to control the remaining tumor at intervals of around three weeks. Tumor response, survival, and adverse events of this combined therapy were assessed.Results: The tumor response was assessed three months after combined TACE, with complete response in 38.1% and partial response in 57.1% of cases. Severe adverse events were seen in two patients, acute cholecystitis and tumor rupture. The median survival time was 2.7 years, and the one-, two-, three-, and five-year overall survival rates were 76.2%, 66.7%, 42.9%, and 25.0%, respectively.Conclusion: Combined therapy involving bland GS-TAE followed by Lip-TACE can be performed safety and may improve survival in patients with huge HCCs.
博士(医学)・乙第1462号・令和2年6月30日
© 2020 Society of Medical Innovation and Technology
This is a post-peer-review, pre-copyedit version of an article published in Minimally invasive therapy and allied technologies. The final authenticated version is available online at: https://doi.org/10.1080/13645706.2020.1725580.
identifier:Minimally invasive therapy and allied technologies Vol.30 No.4 p.221-228 (2021 Aug)
identifier:13645706
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3763
identifier:Minimally invasive therapy and allied technologies., 30(4): 221-228
DOIinfo:doi/10.1080/13645706.2020.1725580
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