Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma

• 資料種別: 博士論文
• ISSN: 1932-6203
• タイトル: Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
• 巻次・部編番号: 15 10
• 著者・編者: 戸次, 鎮宗
• 著者標目: 戸次, 鎮宗
• 出版事項: PLOS
• 出版年月日等: 2022-03-18
• 出版年（W3CDTF）: 2022-03-18
• 並列タイトル等: 血清キヌレニン値は肝細胞癌患者の予後を予測する新規バイオマーカーである
• タイトル（掲載誌）: PLoS ONE
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2022-03-18
• 授与年月日（W3CDTF）: 2022-03-18
• 報告番号: 甲医歯薬第1443号
• 学位: 博士(医学)
• 博論授与番号: 甲医歯薬第1443号
• 本文の言語コード: eng
• 対象利用者: 一般
• 一般注記: Background: We examined serum kynurenine levels in patients with chronic hepatitis C virus infection, and the relationship between serum kynurenine and prognosis in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C.Methods: We retrospectively analyzed 604 patients with HCC diagnosed between January 1999 and December 2015, and 288 patients without HCC who were seen at the National Hospital Organization Nagasaki Medical Center between October 2014 and November 2017. The association between serum kynurenine and prognosis was evaluated using the Cox’s proportional hazards regression analysis.Results: Patients with HCC had significantly higher values of serum kynurenine than patients without HCC (median: 557.1 vs. 464.2 ng/mL, p<0.001). Five-year survival rates of HCC patients with serum kynurenine ≥900 (n = 65), 600–899 (n = 194), and <600 ng/mL (n = 345) were 30.6%, 47.4%, and 61.4%, respectively (p = 0.001, log-rank test). Multivariate analysis identified serum kynurenine as an independent predictor for prognosis of HCC patients. The hazard ratio of serum kynurenine ≥900, and 600–899 compared with serum kynurenine <600 ng/mL were 1.91 (p<0.001) and 1.37 (p = 0.015), respectively.Conclusions: A high level of serum kynurenine correlated with poor prognosis of HCC. Serum kynurenine levels may be a novel biomarker to predict the prognosis of patients with HCC. The development of drugs that inhibit kynurenine production is expected to help improve the prognosis of patients with HCC.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1443号 学位授与年月日:令和4年3月18日; Author: Shigemune Bekki, Satoru Hashimoto, Kazumi Yamasaki, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Akira Saeki, Tomoyuki Suehiro, Yuki Kugiyama, Asami Beppu, Tamotsu Kuroki, Minoru Nakamura, Masahiro Ito, Hiroshi Yatsuhashi; Citation: PLoS ONE, 15(10), art. no. e0241002; 2020; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-03-18); http://hdl.handle.net/10069/00041446
• DOI: info:doi/10.1371/journal.pone.0241002; https://doi.org/info:doi/10.1371/journal.pone.0241002
• 国立国会図書館永続的識別子: info:ndljp/pid/12296392; https://dl.ndl.go.jp/pid/12296392
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2022-06-05T18:01:14+09:00
• 作成日（W3CDTF）: 2022-05-27
• 記録形式（IMT）: PDF
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 関連情報（URI）: http://hdl.handle.net/10069/00041446
• 掲載誌（URI）: http://hdl.handle.net/10069/00041562
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp