External validation of a genitourinary cancer-specific prognostic scoring system to predict survival for patients with bone metastasis (modified B-FOM scoring model): Comparison with other scoring models in terms of accuracy.

• 資料種別: 博士論文
• ISSN: 2212-1366
• タイトル: External validation of a genitourinary cancer-specific prognostic scoring system to predict survival for patients with bone metastasis (modified B-FOM scoring model): Comparison with other scoring models in terms of accuracy.
• 巻次・部編番号: 26
• 著者・編者: Owari, Takuya; Miyake, Makito; Nakai, Yasushi; Tanaka, Nobumichi; Itami, Yoshitaka; Hirao, Shuya; Momose, Hitoshi; Nakagawa, Yoshinori; Iida, Kouta; Maesaka, Fumisato; Shimizu, Takuto; Iemura, Yusuke; Matsumoto, Yoshihiro; Kuwada, Masaomi; Otani, Takeshi; Otsuka, Kenji; Okajima, Eijiro; Hosokawa, Yukinari; Okamura, Ryosuke; Fujimoto, Kiyohide
• 著者標目: Owari, Takuya; Miyake, Makito; Nakai, Yasushi; Tanaka, Nobumichi; Itami, Yoshitaka; Hirao, Shuya; Momose, Hitoshi; Nakagawa, Yoshinori; Iida, Kouta; Maesaka, Fumisato; Shimizu, Takuto; Iemura, Yusuke; Matsumoto, Yoshihiro; Kuwada, Masaomi; Otani, Takeshi; Otsuka, Kenji; Okajima, Eijiro; Hosokawa, Yukinari; Okamura, Ryosuke; Fujimoto, Kiyohide
• 出版事項: Elsevier
• 出版年月日等: 2021-02; 26
• 出版年（W3CDTF）: 2021-02
• 並列タイトル等: 骨転移を有する泌尿器科がんに特化した予後予測スコアリングモデル(B-FOM model)の外部検証および他のスコアリングモデルとの予後予測精度の比較
• タイトル（掲載誌）: Journal of bone oncology
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2022-03-15
• 授与年月日（W3CDTF）: 2022-03-15
• 報告番号: 甲第835号
• 学位: 博士（医学）
• 博論授与番号: 甲第835号
• 本文の言語コード: eng
• 件名標目: Bone metastasis; Genitourinary cancer; Risk scoring model; Predicting survival
• 対象利用者: 一般
• 一般注記: type:Thesis; Objective: We previously developed genitourinary (GU) cancer-specific scoring system for prediction of survival in patients with bone metastasis (the Bone-Fujimoto-Owari-Miyake [B-FOM] scoring model) based on five prognostic factors: the type of primary tumor (prostate cancer (PCa) vs renal cell carcinoma (RCC) and PCa vs urothelial carcinoma (UC)), poor performance status (PS), visceral metastasis, high Glasgow-prognostic score (GPS), elevated neutrophil-to-lymphocyte ratio (NLR). The aim of this study was to externally validate and further improve the performance of the B-FOM score. Methods: The external validation cohort comprised 309 patients with GU cancer with bone metastasis from multiple institutions. Clinical factors were analyzed using Kaplan-Meier method and COX regression hazard model. Performance of a modified B-FOM score was compared to that of other scoring models by the Kaplan-Meier method and the area under the curve (AUC) of receiver operating characteristic curves. Results: The median follow-up period of development and validation cohort were 25 and 17 months, respectively. Kaplan-Meier curve demonstrated that the type of primary tumor (RCC and UC vs PCa), poor PS, presence of visceral metastasis, high GPS, elevated NLR were significantly associated with shorter cancer-specific survival. Risk groups were successfully stratified by the modified B-FOM score classification. Moreover, the AUC of the modified B-FOM scoring model for predicting mortality at 6, 12, and 24 months were 0.895, 0.856, and 0.815, respectively, which were the highest among evaluated models. Conclusions: The B-FOM scoring model is a simple and accurate prediction tool. By using this scoring model at the time of the diagnosis of bone metastasis in patients with GU cancers, an individualized optimal treatment strategy can be selected.; 博士（医学）・甲第835号・令和4年3月15日; © 2020 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license(https://creativecommons.org/licenses/by-nc-nd/4.0/).; identifier:Journal of bone oncology Vol.26 Article No.100344 (2021 Feb); identifier:22121366; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4018; identifier:Journal of bone oncology, 26: Article No.100344
• DOI: info:doi/10.1016/j.jbo.2020.100344; https://doi.org/info:doi/10.1016/j.jbo.2020.100344
• 国立国会図書館永続的識別子: info:ndljp/pid/12296417; https://dl.ndl.go.jp/pid/12296417
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2022-06-05T18:01:14+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/4018
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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