著者・編者Kosugi, Takaaki
Eriguchi, Masahiro
Yoshida, Hisako
Tasaki, Hikari
Fukata, Fumihiro
Nishimoto, Masatoshi
Matsui, Masaru
Samejima, Ken-ichi
Iseki, Kunitoshi
Fujimoto, Shouichi
Konta, Tsuneo
Moriyama, Toshiki
Yamagata, Kunihiro
Narita, Ichiei
Kasahara, Masato
Shibagaki, Yugo
Kondo, Masahide
Asahi, Koichi
Watanabe, Tsuyoshi
Tsuruya, Kazuhiko
Japan Specific Health Checkups (J-SHC) Study Group
並列タイトル等慢性腎臓病と脂質異常症の新規発症との関連の検討 : The Japan Specific Health Checkups (J-SHC) study
一般注記type:Thesis
Background and aims: Dyslipidemias are common among patients with chronic kidney disease (CKD) and are a major risk factor for cardiovascular disease. This study aimed to investigate the association between early-stage CKD and new-onset dyslipidemia for each lipid profile. Methods: This nationwide longitudinal study included data from the Japan Specific Health Checkups (J-SHC) Study. New-onset dyslipidemia was indicated by hypertriglyceridemia (High-TG; ≥150 mg/dL), hyper-LDL cholesterolemia (High-LDL-C; ≥140 mg/dL), or hypo-HDL chelesterolemia (Low-HDL-C; <40 mg/dL) levels according to the guideline of Japan Atherosclerosis Society, or High-TG/HDL-C ratio (≥3.5) which was a good predictor of atherosclerosis. The incidence of new-onset dyslipidemia was compared between participants with and without CKD. Survival curves were used to analyze the incidence of each dyslipidemia. Results: Of 289,462 participants with a median follow-up period of 3 years, the incidence of High-TG, High-LDL-C, Low-HDL-C, and High-TG/HDL-C ratios were 64.4/1000 person-years, 83.1/1000 person-years, 14.5/1000 person-years, and 39.6/1000 person-years, respectively. The adjusted hazard ratios (95% confidence intervals) for High-TG, High-LDL-C, Low-HDL-C, and High-TG/HDL-C ratio were 1.09 (1.05-1.13), 0.99 (0.95-1.04), 1.12 (1.05-1.18), and 1.14 (1.09-1.18), respectively, in CKD participants as compared to non-CKD participants. Decreased eGFR and presence of proteinuria were independently associated with higher risks for new-onset of High-TG, Low-HDL-C, and High-TG/HDL-C ratios. Conclusions: CKD was associated with a higher risk of new-onset High-TG, Low-HDL-C, and High-TG/HDL-C ratios, but not High-LDL-C, in the general population. These CKD-specific lipid abnormalities may explain the residual risk for CKD-related cardiovascular disease.
博士（医学）・甲第823号・令和4年3月15日
Copyright © 2021 Elsevier B.V. All rights reserved.
identifier:Atherosclerosis Vol.332 p.24-32 (2021 Sep)
identifier:00219150
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4006
identifier:Atherosclerosis, 332: 24-32
DOIinfo:doi/10.1016/j.atherosclerosis.2021.08.004
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