Evidence of Chikungunya virus seroprevalence in Myanmar among dengue-suspected patients and healthy volunteers in 2013, 2015, and 2018

• 資料種別: 博士論文
• ISSN: 1935-2735
• タイトル: Evidence of Chikungunya virus seroprevalence in Myanmar among dengue-suspected patients and healthy volunteers in 2013, 2015, and 2018
• 巻次・部編番号: 15 12
• 著者・編者: Luvai, Elizabeth Ajema Chebichi
• 著者標目: Luvai, Elizabeth Ajema Chebichi
• 出版事項: PLOS
• 出版年月日等: 2022-03-18
• 出版年（W3CDTF）: 2022-03-18
• 並列タイトル等: 2013年、2015年、2018年のミャンマー国におけるデング熱疑い患者および、一般健康人のチクングニヤウイルスに対する血清疫学調査
• タイトル（掲載誌）: PLoS Neglected Tropical Diseases
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2022-03-18
• 授与年月日（W3CDTF）: 2022-03-18
• 報告番号: 甲医歯薬第1439号
• 学位: 博士(医学)
• 博論授与番号: 甲医歯薬第1439号
• 本文の言語コード: eng
• 対象利用者: 一般
• 一般注記: Introduction: Chikungunya virus (CHIKV) is a mosquito-borne virus known to cause acute febrile illness associated with debilitating polyarthritis. In 2019, several institutions in Myanmar reported a CHIKV outbreak. There are no official reports of CHIKV cases between 2011 and 2018. Therefore, this study sought to determine the seroprevalence of CHIKV infection before the 2019 outbreak.Methods: A total of 1,544 serum samples were collected from healthy volunteers and patients with febrile illnesses in Yangon, Mandalay, and the Myeik district in 2013, 2015, and 2018. Participants ranged from one month to 65 years of age. Antibody screening was performed with in-house anti-CHIKV IgG and IgM ELISA. A neutralization assay was used as a confirmatory test.Results: The seroprevalence of anti-CHIKV IgM and anti-CHIKV IgG was 8.9% and 28.6%, respectively, with an overall seropositivity rate of 34.5%. A focus reduction neutralization assay confirmed 32.5% seroprevalence of CHIKV in the study population. Age, health status, and region were significantly associated with neutralizing antibodies (NAbs) and CHIKV seropositivity (p < 0.05), while gender was not (p = 0.9). Seroprevalence in 2013, 2015, and 2018 was 32.1%, 28.8%, and 37.3%, respectively. Of the clinical symptoms observed in participants with fevers, arthralgia was mainly noted in CHIKV-seropositive patients.Conclusion: The findings in this study reveal the circulation of CHIKV in Myanmar’s Mandalay, Yangon, and Myeik regions before the 2019 CHIKV outbreak. As no treatment or vaccine for CHIKV exists, the virus must be monitored through systematic surveillance in Myanmar.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1439号 学位授与年月日:令和4年3月18日; Author: Elizabeth Ajema Chebichi Luvai, Aung Kyaw Kyaw, Nundu Sabiti Sabin, Fuxun Yu, Saw Wut Hmone, Kyaw Zin Thant, Shingo Inoue, Kouichi Morita, Mya Myat Ngwe Tun; Citation: PLoS Neglected Tropical Diseases, 15(12), art.no. e0009961; 2021; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-03-18); http://hdl.handle.net/10069/00041442
• DOI: info:doi/10.1371/journal.pntd.0009961; https://doi.org/info:doi/10.1371/journal.pntd.0009961
• 国立国会図書館永続的識別子: info:ndljp/pid/12296680; https://dl.ndl.go.jp/pid/12296680
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2022-06-05T18:01:14+09:00
• 作成日（W3CDTF）: 2022-05-26
• 記録形式（IMT）: PDF
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 関連情報（URI）: http://hdl.handle.net/10069/00041442
• 掲載誌（URI）: http://hdl.handle.net/10069/00041557
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp