並列タイトル等デンタルインプラント表面のオステオポンチンはオッセオインテグレーションにおける直接性骨形成を促進する
一般注記After dental implantation, osteopontin (OPN) is deposited on the hydroxyapatite (HA) blasted implant surface followed by direct osteogenesis, which is significantly disturbed in Opn-knockout (KO) mice. However, whether applying OPN on the implant surface promotes direct osteogenesis remains unclarified. This study analyzed the effects of various OPN modified protein/peptides coating on the healing patterns of the bone-implant interface after immediately placed implantation in the maxilla of four-week-old Opn-KO and wild-type (WT) mice. The decalcified samples were processed for immunohistochemistry for OPN and Ki67 and TRAP histochemistry. In the WT mice, the proliferative activity in the HA binding peptide-OPN mimic peptide fusion coated group was significantly higher than that in the control group from day 3 to week 1, and OPN deposition on the implant surface significantly increased in the recombinant-mouse-OPN (rOPN) group compared to the RGDS group on week 2. The rOPN group achieved the same rates of direct osteogenesis and osseointegration as those in the control group in a half period (on week 2). None of the implant surfaces could rescue the direct osteogenesis in the healing process in the Opn-KO mice. These results suggest that the rOPN coated implant enhances direct osteogenesis during osseointegration following implantation.
International Journal of Molecular Sciences. 2022, 23(3), 1039.
新大院博(歯)第494号
コレクション（個別）国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
受理日（W3CDTF）2022-06-05T18:01:14+09:00
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