Aberrant upregulation of the endogenous PP2A inhibitor CIP2A is vital for myeloma cell growth and survival

• 資料種別: 博士論文
• ISSN: 2187-3143
• タイトル: Aberrant upregulation of the endogenous PP2A inhibitor CIP2A is vital for myeloma cell growth and survival
• 巻次・部編番号: 12 2
• 著者・編者: Shimizu, So; Teramachi, Jumpei; Harada, Takeshi; Hiasa, Masahiro; Tenshin, Hirofumi; Oda, Asuka; Seki, Aiko; Inoue, Yusuke; Tanimoto, Kotaro; Higa, Yoshiki; Oura, Masahiro; Sogabe, Kimiko; Hara, Tomoyo; Sumitani, Ryohei; Maruhashi, Tomoko; Yamagami, Hiroki; Sawa, Yoshihiko; Endo, Itsuro; Tsuneyama, Koichi; Matsumoto, Toshio; Tanaka, Eiji; Abe, Masahiro
• 著者標目: Shimizu, So; Teramachi, Jumpei; Harada, Takeshi; Hiasa, Masahiro; Tenshin, Hirofumi; Oda, Asuka; Seki, Aiko; Inoue, Yusuke; Tanimoto, Kotaro; Higa, Yoshiki; Oura, Masahiro; Sogabe, Kimiko; Hara, Tomoyo; Sumitani, Ryohei; Maruhashi, Tomoko; Yamagami, Hiroki; Sawa, Yoshihiko; Endo, Itsuro; Tsuneyama, Koichi; Matsumoto, Toshio; Tanaka, Eiji; Abe, Masahiro
• 出版事項: Japanese Society of Myeloma
• 出版年月日等: 2022
• 出版年（W3CDTF）: 2022
• 並列タイトル等: 内因性PP2A阻害因CIP2Aの過剰な発現は骨髄腫細胞の増殖・生存に極めて重要である; CIP2A-PP2A in myeloma
• タイトル（掲載誌）: International Journal of Myeloma
• 授与機関名: 徳島大学
• 授与年月日: 2022-05-12
• 授与年月日（W3CDTF）: 2022-05-12
• 報告番号: 甲第3640号
• 学位: 博士（歯学）
• 博論授与番号: 甲第3640号
• 本文の言語コード: eng
• 件名標目: multiple myeloma; TAK1; CIP2A; PP2A
• 対象利用者: 一般
• 一般注記: The serine/threonine kinase TAK1 is constitutively overexpressed and auto-phosphorylated in multiple myeloma (MM) cells. Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase which dephosphorylates proteins phosphorylated by various serine/threonine kinases to regulate multiple cellular functions. We recently reported that the serine/threonine kinase TGF-β-activated kinase-1 (TAK1) is highly expressed and auto-phosphorylated to mediate critical growth and survival signaling in MM cells. We demonstrate here that regulation of PP2A activity inversely affects the phosphorylation levels of TAK1 in MM cells, and that MM cells aberrantly overexpress cancerous inhibitor of PP2A (CIP2A), an endogenous inhibitor for PP2A. CIP2A gene silencing as well as treatment with the CIP2A inhibitor TD52 potently induced MM cell death along with suppression of TAK1 expression in MM cells. These results suggest the critical role of PP2A inactivation via CIP2A upregulation in TAK1 phosphorylation and its protein expression and thereby MM cell growth and survival, posing the CIP2A-PP2A axis as an important therapeutic target.
• 国立国会図書館永続的識別子: info:ndljp/pid/12304023; https://dl.ndl.go.jp/pid/12304023
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2022-07-05T02:30:21+09:00
• 記録形式（IMT）: PDF
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/117150
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp