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博士論文
国立国会図書館館内限定公開
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心血管危険因子は健常者の血栓の増大を促進する : T-TAS®を用いた解析
- 国立国会図書館永続的識別子
- info:ndljp/pid/12304446
- 資料種別
- 博士論文
- 著者
- 尾田, 悠
- 出版者
- BMC
- 出版年
- 2022-02-17
- 資料形態
- デジタル
- ページ数・大きさ等
- -
- 授与大学名・学位
- 鹿児島大学,博士(医学),Doctor of Philosophy in Medical Science
国立国会図書館での利用に関する注記
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- 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Background: Rupture of an atherosclerotic plaque and subsequent exposure of the subendothelial prothrombotic matrix ...
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デジタル
- 資料種別
- 博士論文
- 著者・編者
- 尾田, 悠
- 著者標目
- 出版事項
- 出版年月日等
- 2022-02-17
- 出版年(W3CDTF)
- 2022-02-17
- 並列タイトル等
- Cardiovascular risk factors are associated with augmented thrombogenicity in healthy individuals : analysis using the Total Thrombus-formation Analysis System
- 授与機関名
- 鹿児島大学
- 授与年月日
- 2022-02-17
- 授与年月日(W3CDTF)
- 2022-02-17
- 報告番号
- 甲総研第630号
- 学位
- 博士(医学)Doctor of Philosophy in Medical Science
- 博論授与番号
- 甲総研第630号
- 本文の言語コード
- eng
- NDC
- 対象利用者
- 一般
- 一般注記
- 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Background: Rupture of an atherosclerotic plaque and subsequent exposure of the subendothelial prothrombotic matrix to blood cause arterial thrombosis. Circulating platelets play an indispensable role in the growth of arterial thrombi partially owing to their unique ability to adhere to the subendothelial matrix and to aggregate to each other under flow conditions. Recently, the Total Thrombus-formation Analysis System (T-TAS) was developed for ex vivo analysis of the thrombogenic potential of whole blood samples under flow conditions. Despite the potential clinical utility of the T-TAS in assessing the risk for thrombosis and bleeding, reference intervals for T-TAS analysis in healthy individuals have not been determined.Methods: In total, 122 whole blood samples were collected from healthy volunteers ranging in age from 25 to 45 years. T-TAS analysis and hematological, physiological, and lifestyle assessments were conducted in these subjects. Whole blood samples anticoagulated with hirudin were perfused into a collagen-coated microchip (PL chip). The time to 10 kPa and the area under the flow pressure curve up to 10 min (AUC10) were analyzed as representative variables for thrombogenic potential. Reference intervals, which were defined as 2.5–97.5 percentiles, were determined. Additionally, univariate and multivariate analyses were performed to identify factors associated with the AUC10 in the T-TAS.Results: The time to 10 kPa and the AUC10 widely varied, even in healthy volunteers. The reference intervals were 1.50–4.02 min and 223.4–456.8, respectively, at a shear rate of 1500 s− 1. Univariate and multivariate analyses showed that platelet counts were most significantly associated with the AUC10 of the T-TAS. The presence of one or more cardiovascular risk factors of a high body mass index, a high pulse pressure, high fasting serum glucose levels, high low-density lipoprotein-cholesterol levels, a history of smoking, and no habitual exercise, had the second largest effect on the AUC10 of the T-TAS.Conclusions: Healthy volunteers who had any cardiovascular risk factors showed augmented thrombogenicity, even in artificial uniform capillaries, compared with those without any risk factors in the T-TAS.Yuu Oda, Takashi Ito, Yoichiro Yamada, Tadashi Koga, Tomoka Nagasato, Tomoko Ohnishi-Wada, Kazuya Hosokawa, Hiroyuki Fukase, Teruto Hashiguchi and Ikuro MaruyamaCardiovascular risk factors are associated with augmented thrombogenicity in healthy individuals : analysis using the Total Thrombus-formation Analysis SystemThrombosis Journal (2021) 19:88https://doi.org/10.1186/s12959-021-00341-3
- 国立国会図書館永続的識別子
- info:ndljp/pid/12304446
- コレクション(共通)
- コレクション(障害者向け資料:レベル1)
- コレクション(個別)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- 収集根拠
- 博士論文(自動収集)
- 受理日(W3CDTF)
- 2022-07-05T02:30:21+09:00
- 作成日(W3CDTF)
- 2022-05-23
- 記録形式(IMT)
- PDFapplication/pdf
- オンライン閲覧公開範囲
- 国立国会図書館内限定公開
- デジタル化資料送信
- 図書館・個人送信対象外
- 遠隔複写可否(NDL)
- 可
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館デジタルコレクション